Detail Information

Basic Information:


  VIRBase ID:  

HHID00013040

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           PLOD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 PLOD2
miRBase
Accession/Entrez ID		 MIMAT0005893 5352
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BRKS2//LH2//TLH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLOD2
chr3:145800533(-) A-I      intronic
chr3:145800547(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLOD2
chr3:145787781-145787782(-) m6A 3'UTR       26404942
chr3:145787848-145787849(-) m6A 3'UTR       26404942
chr3:145787902-145787903(-) m6A 3'UTR       27773535
chr3:145787931-145787932(-) m6A 3'UTR       27773535
chr3:145787977-145787978(-) m6A 3'UTR       27773535
chr3:145788016-145788017(-) m6A 3'UTR       27773535
chr3:145788069-145788070(-) m6A 3'UTR//exon       27773535
chr3:145788106-145788107(-) m6A 3'UTR//exon       27773535
chr3:145788177-145788178(-) m6A 3'UTR//exon       27773535
chr3:145788276-145788277(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr3:145788306-145788307(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr3:145788359-145788360(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788370-145788371(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788390-145788391(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788449-145788450(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788538-145788539(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr3:145788557-145788558(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr3:145788578-145788579(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:145788835-145788836(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr3:145788862-145788863(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr3:145790353-145790354(-) m6A CDS//exon       22575960
chr3:145790380-145790381(-) m6A CDS//exon       22575960
chr3:145796991-145796992(-) m6A CDS//exon       22575960
chr3:145804508-145804509(-) m6A exon//intron       24981863
chr3:145804582-145804583(-) m6A CDS//exon       24981863
chr3:145838942-145838943(-) m6A 3'UTR//CDS       24981863//26404942
chr3:145841066-145841067(-) m6A CDS//intron       24981863//26404942
chr3:145878696-145878697(-) m6A 5'UTR//CDS//intron       22575960
chr3:145878858-145878859(-) m6A 5'UTR//intron       27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PLOD2
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: PLOD2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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