Basic Information:

  VIRBase ID:  

HHID00012989

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          LOX:  NM_002317     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	LOX
miRBase Accession/Entrez ID	MIMAT0005893	4015
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AAT10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LOX	chr5:121399323-121399324(-) m6A 3'UTR       27773535 chr5:121399903-121399904(-) m6A 3'UTR       27773535 chr5:121399917-121399918(-) m6A 3'UTR       27773535 chr5:121399970-121399971(-) m6A 3'UTR       27773535 chr5:121400002-121400003(-) m6A 3'UTR       27773535 chr5:121400012-121400013(-) m6A 3'UTR       27773535 chr5:121400022-121400023(-) m6A 3'UTR       27773535 chr5:121400071-121400072(-) m6A 3'UTR       27773535 chr5:121400099-121400100(-) m6A 3'UTR       27773535 chr5:121401960-121401961(-) m6A 3'UTR//exon       27773535 chr5:121401990-121401991(-) m6A 3'UTR//exon       27773535 chr5:121402039-121402040(-) m6A 3'UTR//exon       27773535 chr5:121402050-121402051(-) m6A 3'UTR//exon       27773535 chr5:121402069-121402070(-) m6A 3'UTR//exon       27773535 chr5:121402075-121402076(-) m6A 3'UTR//exon       27773535 chr5:121402305-121402306(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402328-121402329(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402335-121402336(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402373-121402374(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402423-121402424(-) m6A 3'UTR//exon       24981863//22608085 chr5:121411156-121411157(-) m6A 3'UTR//CDS//exon       27773535 chr5:121411164-121411165(-) m6A 3'UTR//CDS//exon       27773535 chr5:121412599-121412600(-) m6A CDS//exon//intron       27773535 chr5:121412771-121412772(-) m6A exon//intron       22608085 chr5:121412894-121412895(-) m6A exon//intron       25456834//24981863//22608085 chr5:121413098-121413099(-) m6A CDS       24284625//24981863//22608085 chr5:121413244-121413245(-) m6A CDS       24284625//24981863//22575960 chr5:121413249-121413250(-) m6A CDS       24284625//24981863//22575960 chr5:121413468-121413469(-) m6A CDS       27773536 chr5:121413531-121413532(-) m6A CDS       27773536 chr5:121413808-121413809(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085 chr5:121413901-121413902(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085 chr5:121413932-121413933(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085 chr5:121413951-121413952(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773536//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	LOX	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: LOX

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).