Basic Information:

  VIRBase ID:  

HHID00012933

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          ETV3:  NM_001145312     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	ETV3
miRBase Accession/Entrez ID	MIMAT0005893	2117
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	METS//PE-1//PE1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ETV3	chr1:157092410-157092411(-) m6A 3'UTR       27773535 chr1:157092424-157092425(-) m6A 3'UTR       24284625//27773535 chr1:157092826-157092827(-) m6A 3'UTR       - chr1:157092892-157092893(-) m6A 3'UTR       - chr1:157093098-157093099(-) m6A 3'UTR       24284625//24981863//27371828 chr1:157093205-157093206(-) m6A 3'UTR       24284625//27371828 chr1:157093344-157093345(-) m6A 3'UTR       24981863//27371828 chr1:157093368-157093369(-) m6A 3'UTR       24981863//27371828 chr1:157093405-157093406(-) m6A 3'UTR       24981863//27371828 chr1:157094181-157094182(-) m6A 3'UTR       24981863 chr1:157094295-157094296(-) m6A 3'UTR       27773535 chr1:157094345-157094346(-) m6A 3'UTR       24981863//27773535 chr1:157094402-157094403(-) m6A 3'UTR       24981863//27773535//22608085 chr1:157094420-157094421(-) m6A 3'UTR       24981863//27773535//22608085 chr1:157094446-157094447(-) m6A 3'UTR       24981863//27773535//22608085 chr1:157094512-157094513(-) m6A 3'UTR       24981863//27773535//22608085 chr1:157094539-157094540(-) m6A 3'UTR       24981863//27773535//22608085 chr1:157094630-157094631(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr1:157094668-157094669(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:157094822-157094823(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr1:157094842-157094843(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr1:157094931-157094932(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr1:157094978-157094979(-) Gm CDS       - chr1:157095022-157095023(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr1:157095107-157095108(-) m6A CDS       24284625//24209618//25456834//27773535//27371828//27773536//22608085 chr1:157095219-157095220(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr1:157095274-157095275(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr1:157095606-157095607(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:157095704-157095705(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr1:157102958-157102959(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27773536//22575960//22608085 chr1:157105470-157105471(-) m6A CDS//exon       24284625//24981863//27371828 chr1:157108122-157108123(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536 chr1:157108133-157108134(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536 chr1:157108138-157108139(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536 chr1:157108261-157108262(-) m6A 5'UTR       25456834//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ETV3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: ETV3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).