Basic Information:

  VIRBase ID:  

HHID00012917

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          DDX10:  NM_004398     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	DDX10
miRBase Accession/Entrez ID	MIMAT0005893	1662
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Dbp4//HRH-J8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDX10	chr11:108621189(+) A-I      intronic chr11:108621188(+) A-I      intronic chr11:108621181(+) A-I      intronic chr11:108621279(+) A-I      intronic chr11:108621175(+) A-I      intronic chr11:108621190(+) A-I      intronic chr11:108621146(+) A-I      intronic chr11:108621149(+) A-I      intronic chr11:108621153(+) A-I      intronic chr11:108621156(+) A-I      intronic chr11:108621161(+) A-I      intronic chr11:108621257(+) A-I      intronic chr11:108621178(+) A-I      intronic chr11:108621268(+) A-I      intronic chr11:108600451(+) A-I      intronic chr11:108600475(+) A-I      intronic chr11:108658546(+) A-I      intronic chr11:108670777(+) A-I      intronic chr11:108544863(+) A-I      intronic chr11:108616189(+) A-I      intronic chr11:108616233(+) A-I      intronic chr11:108616234(+) A-I      intronic chr11:108545009(+) A-I      intronic chr11:108758441(+) A-I      intronic chr11:108545454(+) A-I      intronic chr11:108599321(+) A-I      intronic chr11:108616239(+) A-I      intronic chr11:108635298(+) A-I      intronic chr11:108674131(+) A-I      intronic chr11:108674156(+) A-I      intronic chr11:108674159(+) A-I      intronic chr11:108674163(+) A-I      intronic chr11:108674326(+) A-I      intronic chr11:108683634(+) A-I      intronic chr11:108707277(+) A-I      intronic chr11:108726267(+) A-I      intronic chr11:108545006(+) A-I      intronic chr11:108758435(+) A-I      intronic chr11:108732934(+) A-I      intronic chr11:108732606(+) A-I      intronic chr11:108581705(+) A-I      intronic chr11:108544965(+) A-I      intronic chr11:108616107(+) A-I      intronic chr11:108732911(+) A-I      intronic chr11:108539960(+) A-I      intronic chr11:108586128(+) A-I      intronic chr11:108674242(+) A-I      intronic chr11:108726348(+) A-I      intronic chr11:108726353(+) A-I      intronic chr11:108732845(+) A-I      intronic chr11:108732820(+) A-I      intronic chr11:108732539(+) A-I      intronic chr11:108732563(+) A-I      intronic chr11:108707275(+) A-I      intronic chr11:108545503(+) A-I      intronic chr11:108539954(+) A-I      intronic chr11:108544796(+) A-I      intronic chr11:108707487(+) A-I      intronic chr11:108707278(+) A-I      intronic chr11:108770720(+) A-I      intronic chr11:108770711(+) A-I      intronic chr11:108545517(+) A-I      intronic chr11:108545524(+) A-I      intronic chr11:108565353(+) A-I      intronic chr11:108545429(+) A-I      intronic chr11:108588622(+) A-I      intronic chr11:108675156(+) A-I      intronic chr11:108787860(+) A-I      intronic chr11:108588771(+) A-I      intronic chr11:108588772(+) A-I      intronic chr11:108588136(+) A-I      intronic chr11:108599316(+) A-I      intronic chr11:108621134(+) A-I      intronic chr11:108612885(+) A-I      intronic chr11:108622345(+) A-I      intronic chr11:108622323(+) A-I      intronic chr11:108572514(+) A-I      intronic chr11:108726205(+) A-I      intronic chr11:108773738(+) A-I      intronic chr11:108727014(+) A-I      intronic chr11:108704731(+) A-I      intronic chr11:108588166(+) A-I      intronic chr11:108599327(+) A-I      intronic chr11:108676952(+) A-I      intronic chr11:108787837(+) A-I      intronic chr11:108622351(+) A-I      intronic chr11:108616080(+) A-I      intronic chr11:108704703(+) A-I      intronic chr11:108588163(+) A-I      intronic chr11:108612822(+) A-I      intronic chr11:108622236(+) A-I      intronic chr11:108613242(+) A-I      intronic chr11:108727079(+) A-I      intronic chr11:108727073(+) A-I      intronic chr11:108674144(+) A-I      intronic chr11:108588628(+) A-I      intronic chr11:108726362(+) A-I      intronic chr11:108658459(+) A-I      intronic chr11:108588176(+) A-I      intronic chr11:108727010(+) A-I      intronic chr11:108658640(+) A-I      intronic chr11:108622237(+) A-I      intronic chr11:108599262(+) A-I      intronic chr11:108683562(+) A-I      intronic chr11:108599335(+) A-I      intronic chr11:108602074(+) A-I      intronic chr11:108622475(+) A-I      intronic chr11:108588824(+) A-I      intronic chr11:108599259(+) A-I      intronic chr11:108544873(+) A-I      intronic chr11:108612730(+) A-I      intronic chr11:108622563(+) A-I      intronic chr11:108574083(+) A-I      intronic chr11:108576961(+) A-I      intronic chr11:108787856(+) A-I      intronic chr11:108621356(+) A-I      intronic chr11:108732632(+) A-I      intronic chr11:108726206(+) A-I      intronic chr11:108599261(+) A-I      intronic chr11:108588821(+) A-I      intronic chr11:108622178(+) A-I      intronic chr11:108612867(+) A-I      intronic chr11:108622318(+) A-I      intronic chr11:108727001(+) A-I      intronic chr11:108622534(+) A-I      intronic chr11:108658647(+) A-I      intronic chr11:108683629(+) A-I      intronic chr11:108671061(+) A-I      intronic chr11:108600464(+) A-I      intronic chr11:108621133(+) A-I      intronic chr11:108622474(+) A-I      intronic chr11:108621008(+) A-I      intronic chr11:108545515(+) A-I      intronic chr11:108600456(+) A-I      intronic chr11:108622220(+) A-I      intronic chr11:108707283(+) A-I      intronic chr11:108622179(+) A-I      intronic chr11:108622438(+) A-I      intronic chr11:108622533(+) A-I      intronic chr11:108732885(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DDX10	chr11:108792863(+) T-C intron -    21725310 chr11:108622323(+) A-G intron -    22484847 chr11:108622345(+) A-G intron -    22484847 chr11:108773738(+) A-G intron -    22484847 chr11:108612730(+) A-G intron -    22484847 chr11:108621356(+) A-G intron -    22484847 chr11:108622237(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDX10	chr11:108535957-108535958(+) m6A CDS//exon       24981863 chr11:108535974-108535975(+) m6A CDS//exon       24981863 chr11:108536008-108536009(+) m6A CDS//exon       24981863 chr11:108536055-108536056(+) m6A CDS//exon       24981863 chr11:108593777-108593778(+) m6A CDS       24284625//24981863//27773535//22608085 chr11:108593918-108593919(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr11:108593928-108593929(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr11:108593939-108593940(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr11:108593966-108593967(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr11:108594008-108594009(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:108594097-108594098(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:108594163-108594164(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr11:108594180-108594181(+) m6A CDS       24284625//25456834//24981863//22608085 chr11:108638057-108638058(+) m6A exon//intron       24284625//25456834//24981863//22608085 chr11:108638062-108638063(+) m6A exon//intron       25456834//24981863//22608085 chr11:108638070-108638071(+) m6A exon//intron       25456834//24981863//22608085 chr11:108638116-108638117(+) m6A exon//intron       22608085 chr11:108709180-108709181(+) m6A CDS//exon       24981863//22608085 chr11:108712139-108712140(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108712153-108712154(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr11:108722887-108722888(+) m6A CDS       24284625//24981863//27773535//22608085 chr11:108722926-108722927(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr11:108731367-108731368(+) m6A exon//intron       25456834//24981863//27773535//22608085 chr11:108731408-108731409(+) m6A exon//intron       27773535//22608085 chr11:108739021-108739022(+) m6A exon//intron       24981863//22608085 chr11:108739050-108739051(+) m6A exon//intron       24981863//27773535//22608085 chr11:108788815-108788816(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr11:108792960-108792961(+) m6A 3'UTR//intron       24981863 chr11:108800310-108800311(+) m6A exon//intron       24981863 chr11:108800383-108800384(+) m6A exon//intron       24209618//24981863//22608085 chr11:108811032-108811033(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:108811067-108811068(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:108811179-108811180(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr11:108811215-108811216(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr11:108811311-108811312(+) m6A 3'UTR//exon       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	DDX10	Chromatin HCC cell line (HepG2)|K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: DDX10

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).