Basic Information:

  VIRBase ID:  

HHID00012915

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          DCK:  NM_000788     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	DCK
miRBase Accession/Entrez ID	MIMAT0005893	1633
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCK	chr4:71871471(+) A-I      intronic chr4:71871482(+) A-I      intronic chr4:71871493(+) A-I      intronic chr4:71894224(+) A-I      intronic chr4:71887559(+) A-I      intronic chr4:71883914(+) A-I      intronic chr4:71883913(+) A-I      intronic chr4:71876747(+) A-I      intronic chr4:71871696(+) A-I      intronic chr4:71861812(+) A-I      intronic chr4:71894164(+) A-I      intronic chr4:71887647(+) A-I      intronic chr4:71887598(+) A-I      intronic chr4:71894476(+) A-I      intronic chr4:71894047(+) A-I      intronic chr4:71871439(+) A-I      intronic chr4:71894369(+) A-I      Syn:Gln->Gln chr4:71887491(+) A-I      intronic chr4:71861819(+) A-I      intronic chr4:71861713(+) A-I      intronic chr4:71871366(+) A-I      intronic chr4:71871402(+) A-I      intronic chr4:71894158(+) A-I      intronic chr4:71861042(+) A-I      intronic chr4:71894099(+) A-I      intronic chr4:71894127(+) A-I      intronic chr4:71864561(+) A-I      intronic chr4:71894811(+) A-I      intronic chr4:71894374(+) A-I      NonSyn:His->Arg

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCK	chr4:71871366(+) A-G intron -    22484847 chr4:71871439(+) A-G intron -    22484847 chr4:71885509(+) A-T intron -    22484847 chr4:71887491(+) A-G intron -    22484847 chr4:71894369(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCK	chr4:71859283-71859284(+) m6A 5'UTR//intron       24981863 chr4:71859399-71859400(+) m6A 5'UTR//intron       24981863 chr4:71859544-71859545(+) m6A 5'UTR       24284625 chr4:71859606-71859607(+) m6A CDS       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	DCK	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: DCK

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).