Detail Information

Basic Information:


  VIRBase ID:  

HHID00012906

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           COPA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 COPA
miRBase
Accession/Entrez ID		 MIMAT0005893 1314
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AILJK//alpha-COP//HEP-COP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR COPA
chr1:160259486(-) A-I      3'UTR
chr1:160259487(-) A-I      3'UTR
chr1:160302981(-) A-I      intronic
chr1:160259477(-) A-I      3'UTR
chr1:160302964(-) A-I      intronic
chr1:160259537(-) A-I      3'UTR
chr1:160259545(-) A-I      3'UTR
chr1:160259496(-) A-I      3'UTR
chr1:160259605(-) A-I      3'UTR
chr1:160259557(-) A-I      3'UTR
chr1:160296195(-) A-I      intronic
chr1:160291063(-) A-I      intronic
chr1:160259441(-) A-I      3'UTR
chr1:160296205(-) A-I      intronic
chr1:160296209(-) A-I      intronic
chr1:160259645(-) A-I      3'UTR
chr1:160302956(-) A-I      intronic
chr1:160259563(-) A-I      3'UTR
chr1:160259577(-) A-I      3'UTR
chr1:160259473(-) A-I      3'UTR
chr1:160302878(-) A-I      intronic
chr1:160274306(-) A-I      intronic
chr1:160293717(-) A-I      intronic
chr1:160302995(-) A-I      intronic
chr1:160293857(-) A-I      intronic
chr1:160274050(-) A-I      intronic
chr1:160273998(-) A-I      intronic
chr1:160274226(-) A-I      intronic
chr1:160274071(-) A-I      intronic
chr1:160302890(-) A-I      intronic
chr1:160293737(-) A-I      intronic
chr1:160274291(-) A-I      intronic
chr1:160293748(-) A-I      intronic
chr1:160302887(-) A-I      intronic
chr1:160273916(-) A-I      intronic
chr1:160274392(-) A-I      intronic
chr1:160274271(-) A-I      intronic
chr1:160302965(-) A-I      intronic
chr1:160274372(-) A-I      intronic
chr1:160274407(-) A-I      intronic
chr1:160293856(-) A-I      intronic
chr1:160296082(-) A-I      intronic
chr1:160302951(-) A-I      intronic
chr1:160290245(-) A-I      intronic
chr1:160296162(-) A-I      intronic
chr1:160274212(-) A-I      intronic
chr1:160273888(-) A-I      intronic
chr1:160272616(-) A-I      intronic
chr1:160274367(-) A-I      intronic
chr1:160286065(-) A-I      intronic
chr1:160273937(-) A-I      intronic
chr1:160297241(-) A-I      intronic
chr1:160259521(-) A-I      3'UTR
chr1:160274022(-) A-I      intronic
chr1:160259519(-) A-I      3'UTR
chr1:160302917(-) A-I      intronic
chr1:160259670(-) A-I      3'UTR
chr1:160274199(-) A-I      intronic
chr1:160259505(-) A-I      3'UTR
chr1:160259632(-) A-I      3'UTR
chr1:160274332(-) A-I      intronic
chr1:160259613(-) A-I      3'UTR
chr1:160272549(-) A-I      intronic
chr1:160259558(-) A-I      3'UTR
chr1:160259513(-) A-I      3'UTR
chr1:160259549(-) A-I      3'UTR
chr1:160259608(-) A-I      3'UTR
chr1:160274371(-) A-I      intronic
chr1:160273901(-) A-I      intronic
chr1:160302244(-) A-I      NonSyn:Ile->Val
chr1:160296551(-) A-I      intronic
chr1:160297834(-) A-I      intronic
chr1:160296546(-) A-I      intronic
chr1:160272780(-) A-I      intronic
chr1:160274444(-) A-I      intronic
chr1:160259382(-) A-I      3'UTR
chr1:160272733(-) A-I      intronic
chr1:160272547(-) A-I      intronic
chr1:160274011(-) A-I      intronic
chr1:160269261(-) A-I      intronic
chr1:160307253(-) A-I      intronic
chr1:160274211(-) A-I      intronic
chr1:160294141(-) A-I      intronic
chr1:160302986(-) A-I      intronic
chr1:160272700(-) A-I      intronic
chr1:160273834(-) A-I      intronic
chr1:160273942(-) A-I      intronic
chr1:160274391(-) A-I      intronic
chr1:160272953(-) A-I      intronic
chr1:160259532(-) A-I      3'UTR
chr1:160302854(-) A-I      intronic
chr1:160296311(-) A-I      intronic
chr1:160273907(-) A-I      intronic
chr1:160273997(-) A-I      intronic
chr1:160284184(-) A-I      intronic
chr1:160272771(-) A-I      intronic
chr1:160296528(-) A-I      intronic
chr1:160272483(-) A-I      intronic
chr1:160273865(-) A-I      intronic
chr1:160302842(-) A-I      intronic
chr1:160274354(-) A-I      intronic
chr1:160297851(-) A-I      intronic
chr1:160273873(-) A-I      intronic
chr1:160274076(-) A-I      intronic
chr1:160302907(-) A-I      intronic
chr1:160272942(-) A-I      intronic
chr1:160274342(-) A-I      intronic
chr1:160273943(-) A-I      intronic
chr1:160273920(-) A-I      intronic
chr1:160299775(-) A-I      intronic
chr1:160296193(-) A-I      intronic
chr1:160259654(-) A-I      3'UTR
chr1:160272783(-) A-I      intronic
chr1:160273933(-) A-I      intronic
chr1:160296524(-) A-I      intronic
chr1:160296534(-) A-I      intronic
chr1:160259660(-) A-I      3'UTR
chr1:160297835(-) A-I      intronic
chr1:160274077(-) A-I      intronic
chr1:160302970(-) A-I      intronic
chr1:160287374(-) A-I      intronic
chr1:160272718(-) A-I      intronic
chr1:160296547(-) A-I      intronic
chr1:160272778(-) A-I      intronic
chr1:160297875(-) A-I      intronic
chr1:160258766(-) A-I      3'UTR
chr1:160273983(-) A-I      intronic
chr1:160273814(-) A-I      intronic
chr1:160296099(-) A-I      intronic
chr1:160272823(-) A-I      intronic
chr1:160298274(-) A-I      intronic
chr1:160274442(-) A-I      intronic
chr1:160297879(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED COPA
chr1:160302244(-) A-I exon CDS    19478186   //21960545
chr1:160287358(-) A-I intron -    22327324
chr1:160287374(-) A-I intron -    22327324
chr1:160259505(-) A-I exon 3'UTR    22028664
chr1:160259513(-) A-I exon 3'UTR    22028664
chr1:160259519(-) A-I exon 3'UTR    22028664
chr1:160259521(-) A-I exon 3'UTR    22028664
chr1:160259549(-) A-I exon 3'UTR    22028664
chr1:160259558(-) A-I exon 3'UTR    22028664
chr1:160259608(-) A-I exon 3'UTR    22028664
chr1:160259613(-) A-I exon 3'UTR    22028664
chr1:160259632(-) A-I exon 3'UTR    22028664
chr1:160296528(-) A-I intron -    21960545
chr1:160296534(-) A-I intron -    21960545
chr1:160297834(-) A-I intron -    21960545
chr1:160297835(-) A-I intron -    21960545
chr1:160297851(-) A-I intron -    21960545
chr1:160297879(-) A-I intron -    21960545
chr1:160297915(-) A-I intron -    21960545
chr1:160304051(-) A-I intron -    21960545
chr1:160299541(-) T-G intron -    22484847
chr1:160259383(-) G-A exon 3'UTR    22484847
chr1:160259385(-) A-G exon 3'UTR    22484847
chr1:160259483(-) G-A exon 3'UTR    22484847
chr1:160259521(-) A-G exon 3'UTR    22484847
chr1:160267851(-) C-T intron -    22484847
chr1:160267980(-) C-T intron -    22484847
chr1:160270832(-) G-A intron -    22484847
chr1:160272483(-) A-G intron -    22484847
chr1:160272549(-) A-G intron -    22484847
chr1:160272771(-) A-G intron -    22484847
chr1:160272778(-) A-G intron -    22484847
chr1:160272780(-) A-G intron -    22484847
chr1:160272783(-) A-G intron -    22484847
chr1:160272823(-) A-G intron -    22484847
chr1:160272942(-) A-G intron -    22484847
chr1:160272953(-) A-G intron -    22484847
chr1:160273997(-) A-G intron -    22484847
chr1:160274011(-) A-G intron -    22484847
chr1:160274076(-) A-G intron -    22484847
chr1:160274199(-) A-G intron -    22484847
chr1:160274332(-) A-G intron -    22484847
chr1:160274342(-) A-G intron -    22484847
chr1:160274354(-) A-G intron -    22484847
chr1:160274367(-) A-G intron -    22484847
chr1:160274371(-) A-G intron -    22484847
chr1:160274391(-) A-G intron -    22484847
chr1:160274442(-) A-G intron -    22484847
chr1:160301210(-) T-A intron -    22484847
chr1:160301301(-) A-C intron -    22484847
chr1:160301567(-) T-A intron -    22484847
chr1:160302902(-) G-A intron -    22484847
chr1:160307494(-) T-C intron -    22484847
chr1:160307512(-) T-G intron -    22484847
chr1:160307539(-) G-T intron -    22484847
chr1:160307542(-) T-G intron -    22484847
chr1:160307547(-) T-G intron -    22484847
chr1:160296546(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase COPA
chr1:160259217-160259218(-) m6A 3'UTR       24284625//22575960
chr1:160259366-160259367(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr1:160259378-160259379(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr1:160259407-160259408(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr1:160259476-160259477(-) m6A 3'UTR       24284625//24981863//22608085
chr1:160259596-160259597(-) m6A 3'UTR       24284625//24981863//22575960
chr1:160259685-160259686(-) m6A 3'UTR       24284625//24981863
chr1:160259695-160259696(-) m6A 3'UTR       24284625//24981863//26404942
chr1:160259741-160259742(-) Y 3'UTR       25219674
chr1:160259779-160259780(-) m6A 3'UTR       24284625//24981863
chr1:160259822-160259823(-) m6A 3'UTR       27773535
chr1:160264298-160264299(-) m1A CDS       26863410//26863196
chr1:160264322-160264323(-) m1A CDS       26863410//26863196
chr1:160264330-160264331(-) m6A CDS       24981863//26404942//27371828//22575960
chr1:160265525-160265526(-) Gm CDS//exon       -
chr1:160265641-160265642(-) m6A CDS//exon       27371828
chr1:160265852-160265853(-) m6A CDS//exon       27371828
chr1:160265873-160265874(-) m6A CDS//exon       27371828
chr1:160267136-160267137(-) m6A CDS//exon       26404942//27371828
chr1:160267143-160267144(-) m6A CDS//exon       26404942//27371828
chr1:160267212-160267213(-) m6A CDS//exon       26404942//27371828
chr1:160267416-160267417(-) m6A CDS//exon       26404942//22575960
chr1:160267455-160267456(-) m6A CDS//exon       26404942//22575960
chr1:160267497-160267498(-) m6A CDS//exon       26404942//22575960
chr1:160268641-160268642(-) m6A CDS//exon       26404942//22575960
chr1:160268672-160268673(-) m6A CDS//exon       26404942//22575960
chr1:160268754-160268755(-) m6A CDS//exon       22575960
chr1:160268976-160268977(-) m6A CDS//exon       22575960
chr1:160269034-160269035(-) m6A CDS//exon       22575960
chr1:160269051-160269052(-) m6A CDS//exon       22575960
chr1:160275309-160275310(-) m6A CDS//exon       -
chr1:160275338-160275339(-) m6A CDS//exon       -
chr1:160276968-160276969(-) Tm CDS       -
chr1:160293300-160293301(-) m6A CDS       22575960
chr1:160295364-160295365(-) m6A CDS       22575960
chr1:160309346-160309347(-) m6A exon//intron       27773535
chr1:160309439-160309440(-) m6A exon//intron       27773535
chr1:160309977-160309978(-) m6A CDS//exon       22575960
chr1:160310014-160310015(-) m6A CDS//exon       27371828//27773536//22575960
chr1:160310061-160310062(-) m6A CDS//exon       27371828//27773536//22575960
chr1:160312941-160312942(-) m6A CDS//exon       25456834//24981863//27371828//27773536//22575960
chr1:160312944-160312945(-) Gm CDS//exon       -
chr1:160312968-160312969(-) m6A 5'UTR//exon       25456834//24981863//27371828//27773536
chr1:160312983-160312984(-) m6A 5'UTR//exon       24284625//25456834//24981863//27371828//27773536
chr1:160313052-160313053(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22608085
chr1:160313085-160313086(-) m6A 5'UTR       24284625//25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
COPA
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: COPA

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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