Basic Information:

  VIRBase ID:  

HHID00012889

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:  MIMAT0005893          CAV1:  NM_001172897     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1305	CAV1
miRBase Accession/Entrez ID	MIMAT0005893	857
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BSCL3//CGL3//LCCNS//MSTP085//PPH3//VIP21

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1305	rs1391055872 chr4:182169359    G/A rs1460502740 chr4:182169360    A/G rs190183451 chr4:182169358    G/A rs760149578 chr4:182169357    G/T rs774577022 chr4:182169356    T/C rs911409575 chr4:182169355    A/C rs911409575 chr4:182169355    A/G rs931724077 chr4:182169352    C/G rs971149992 chr4:182169361    G/A rs985999312 chr4:182169354    A/G rs1192955520 chr4:182169349    A/G rs1240810346 chr4:182169350    C/A rs1240810346 chr4:182169350    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAV1	chr7:116173162(+) A-I      intronic chr7:116173173(+) A-I      intronic chr7:116173236(+) A-I      intronic chr7:116173260(+) A-I      intronic chr7:116173607(+) A-I      intronic chr7:116173600(+) A-I      intronic chr7:116174639(+) A-I      intronic chr7:116174661(+) A-I      intronic chr7:116173247(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAV1	chr7:116173289(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAV1	chr7:116164900-116164901(+) m6A 5'UTR       24981863 chr7:116164919-116164920(+) m6A 5'UTR       24981863 chr7:116164957-116164958(+) m6A 5'UTR       24981863 chr7:116164961-116164962(+) m6A 5'UTR       24981863 chr7:116165081-116165082(+) m6A 5'UTR//exon       24981863//26404942 chr7:116165138-116165139(+) m6A 5'UTR//CDS//exon       24981863//26404942 chr7:116165554-116165555(+) m6A 3'UTR//5'UTR//intron       24981863 chr7:116165566-116165567(+) m6A 3'UTR//5'UTR//intron       24981863 chr7:116165586-116165587(+) m6A 3'UTR//5'UTR//intron       24981863 chr7:116165641-116165642(+) m6A 3'UTR//5'UTR//intron       24981863 chr7:116165653-116165654(+) m6A 3'UTR//5'UTR//intron       24981863 chr7:116165701-116165702(+) m6A 3'UTR//5'UTR//intron       24981863 chr7:116165716-116165717(+) m6A 3'UTR//5'UTR//intron       24981863 chr7:116166580-116166581(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863//26404942//22575960 chr7:116166607-116166608(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863//26404942 chr7:116166718-116166719(+) m6A 3'UTR//CDS//exon       24981863//26404942 chr7:116166776-116166777(+) m6A exon//intron       26404942 chr7:116199025-116199026(+) m6A 3'UTR//CDS       24284625//24981863//26404942 chr7:116199035-116199036(+) m6A 3'UTR//CDS       24284625//24981863//26404942 chr7:116199547-116199548(+) m6A 3'UTR       24284625//24209618//24981863//26404942 chr7:116199620-116199621(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr7:116199658-116199659(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:116199689-116199690(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:116199797-116199798(+) m6A 3'UTR       24284625//24209618//26404942 chr7:116199885-116199886(+) m6A 3'UTR       26404942 chr7:116199989-116199990(+) m6A 3'UTR       26404942 chr7:116200230-116200231(+) m6A 3'UTR       26404942 chr7:116200365-116200366(+) m6A 3'UTR       24284625//26404942 chr7:116200489-116200490(+) m6A 3'UTR       24284625//24981863//26404942//22575960 chr7:116200570-116200571(+) m6A 3'UTR       24284625//24981863//26404942//22575960 chr7:116200669-116200670(+) m6A 3'UTR       24284625//24981863//26404942 chr7:116200675-116200676(+) m6A 3'UTR       24284625//24981863//26404942 chr7:116200696-116200697(+) m6A 3'UTR       24284625//24981863//26404942 chr7:116200777-116200778(+) m6A 3'UTR       24284625//24981863//26404942 chr7:116200788-116200789(+) m6A 3'UTR       24284625//24981863//26404942 chr7:116200826-116200827(+) m6A 3'UTR       24981863//26404942 chr7:116200909-116200910(+) m6A 3'UTR       24981863//26404942 chr7:116200943-116200944(+) m6A 3'UTR       24981863//26404942 chr7:116201056-116201057(+) m6A 3'UTR       26404942 chr7:116201071-116201072(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1305	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CAV1	Cytosol HeLa-S3 cells     - Exosome Blood     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1305	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1305
Interactor2: CAV1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).