Detail Information

Basic Information:


  VIRBase ID:  

HHID00012874

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1305:           BCL6:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1305 BCL6
miRBase
Accession/Entrez ID		 MIMAT0005893 604
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BCL5//BCL6A//LAZ3//ZBTB27//ZNF51

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1305
rs1391055872 chr4:182169359    G/A
rs1460502740 chr4:182169360    A/G
rs190183451 chr4:182169358    G/A
rs760149578 chr4:182169357    G/T
rs774577022 chr4:182169356    T/C
rs911409575 chr4:182169355    A/C
rs911409575 chr4:182169355    A/G
rs931724077 chr4:182169352    C/G
rs971149992 chr4:182169361    G/A
rs985999312 chr4:182169354    A/G
rs1192955520 chr4:182169349    A/G
rs1240810346 chr4:182169350    C/A
rs1240810346 chr4:182169350    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BCL6
chr3:187442376-187442377(-) m6A exon//intron       27773535
chr3:187442435-187442436(-) m6A exon//intron       27773535
chr3:187443309-187443310(-) m6A 3'UTR//CDS//exon       27773535
chr3:187443354-187443355(-) m6A 3'UTR//CDS//exon       27773535
chr3:187443409-187443410(-) m6A 3'UTR//CDS//exon       27773535
chr3:187444530-187444531(-) m6A 3'UTR//CDS//intron       27773535
chr3:187444594-187444595(-) m6A 3'UTR//CDS//intron       27773535
chr3:187444608-187444609(-) m6A 3'UTR//CDS//intron       27773535
chr3:187446177-187446178(-) m6A 3'UTR//CDS       27773535
chr3:187446882-187446883(-) m6A 3'UTR//CDS       24284625//27773535//27371828
chr3:187446927-187446928(-) m6A 3'UTR//CDS       24284625//27773535//27371828
chr3:187447019-187447020(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828
chr3:187447221-187447222(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535
chr3:187447277-187447278(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535
chr3:187447284-187447285(-) m1A 3'UTR//CDS       26863196
chr3:187447346-187447347(-) m6A 3'UTR//CDS       24284625//24981863//27773535
chr3:187447402-187447403(-) m6A 3'UTR//CDS       24284625//24981863//27773535
chr3:187447698-187447699(-) m6A 3'UTR//CDS       27773535
chr3:187447734-187447735(-) m6A 3'UTR//CDS       27773535
chr3:187451485-187451486(-) m6A 5'UTR//exon       27371828
chr3:187463203-187463204(-) m6A 5'UTR//exon       -
chr3:187463252-187463253(-) m6A 5'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1305
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
BCL6
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1305
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1305
Interactor2: BCL6

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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