Basic Information:

  VIRBase ID:  

HHID00012826

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          CHURC1-FNTB:  NM_001202558     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	CHURC1-FNTB
miRBase Accession/Entrez ID	MIMAT0004811	100529261
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FNTB//FTase-beta

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CHURC1-FNTB	chr14:65442199(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CHURC1-FNTB	chr14:65392761-65392762(+) m6A CDS//intron       - chr14:65399256-65399257(+) m6A intron       22608085 chr14:65399262-65399263(+) m6A intron       27773535//22608085 chr14:65399278-65399279(+) m6A intron       27773535//22608085 chr14:65399290-65399291(+) m6A intron       24284625//27773535//22608085 chr14:65399302-65399303(+) m6A intron       24284625//27773535//22608085 chr14:65399404-65399405(+) m6A intron       24284625//24981863//27773535//22608085 chr14:65399479-65399480(+) m6A intron       24981863 chr14:65399895-65399896(+) m6A intron       24981863 chr14:65399914-65399915(+) m6A intron       24981863 chr14:65399930-65399931(+) m6A intron       24981863 chr14:65399961-65399962(+) m6A intron       24981863 chr14:65400969-65400970(+) m6A intron       24981863 chr14:65400986-65400987(+) m6A intron       24981863 chr14:65401045-65401046(+) m6A intron       24981863 chr14:65401055-65401056(+) m6A intron       24981863 chr14:65401069-65401070(+) m6A intron       24981863 chr14:65401075-65401076(+) m6A intron       24981863 chr14:65401080-65401081(+) m6A intron       24981863 chr14:65401085-65401086(+) m6A intron       24981863 chr14:65401754-65401755(+) m6A intron       - chr14:65401789-65401790(+) m6A intron       24981863 chr14:65401801-65401802(+) m6A intron       24981863 chr14:65401808-65401809(+) m6A intron       24981863 chr14:65401813-65401814(+) m6A intron       24981863 chr14:65401847-65401848(+) m6A intron       24981863 chr14:65401856-65401857(+) m6A intron       24981863 chr14:65401866-65401867(+) m6A intron       24981863 chr14:65401878-65401879(+) m6A intron       24981863 chr14:65401894-65401895(+) m6A intron       24981863 chr14:65410167-65410168(+) m6A intron       24209618//24981863//22608085 chr14:65410294-65410295(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr14:65410306-65410307(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr14:65410319-65410320(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr14:65410341-65410342(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr14:65410361-65410362(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr14:65410496-65410497(+) m6A intron       25456834//24981863//22608085 chr14:65410544-65410545(+) m6A intron       24981863//22608085 chr14:65410553-65410554(+) m6A intron       24981863//22608085 chr14:65410618-65410619(+) m6A intron       24981863//22608085 chr14:65453794-65453795(+) m6A intron       - chr14:65453811-65453812(+) m6A intron       - chr14:65454104-65454105(+) m6A intron       - chr14:65454128-65454129(+) m6A intron       - chr14:65527927-65527928(+) m6A 3'UTR//CDS       24209618 chr14:65527932-65527933(+) m6A 3'UTR//CDS       24209618 chr14:65528003-65528004(+) m6A 3'UTR//CDS       24209618//24981863//22608085 chr14:65528033-65528034(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr14:65528077-65528078(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr14:65528170-65528171(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528175-65528176(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528198-65528199(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528239-65528240(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528276-65528277(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:65528416-65528417(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr14:65528500-65528501(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CHURC1-FNTB	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: CHURC1-FNTB

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).