Basic Information:

  VIRBase ID:  

HHID00012816

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          MTHFD2L:  NM_001351331     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	MTHFD2L
miRBase Accession/Entrez ID	MIMAT0004811	441024
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MTHFD2L	chr4:75104202(+) A-I      intronic chr4:75037400(+) A-I      intronic chr4:75037399(+) A-I      intronic chr4:75104200(+) A-I      intronic chr4:75107264(+) A-I      intronic chr4:75104181(+) A-I      intronic chr4:75158837(+) A-I      intronic chr4:75104194(+) A-I      intronic chr4:75029651(+) A-I      intronic chr4:75098508(+) A-I      intronic chr4:75037338(+) A-I      intronic chr4:75104195(+) A-I      intronic chr4:75104171(+) A-I      intronic chr4:75107147(+) A-I      intronic chr4:75029867(+) A-I      intronic chr4:75037373(+) A-I      intronic chr4:75096295(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MTHFD2L	chr4:75107147(+) A-G intron -    22484847 chr4:75107211(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTHFD2L	chr4:75048488-75048489(+) m6A 3'UTR//intron       22608085 chr4:75048499-75048500(+) m6A 3'UTR//intron       22608085 chr4:75048510-75048511(+) m6A 3'UTR//intron       22608085 chr4:75048577-75048578(+) m6A 3'UTR//intron       22608085 chr4:75048635-75048636(+) m6A 3'UTR//intron       22608085 chr4:75048869-75048870(+) m6A 3'UTR//intron       22608085 chr4:75048896-75048897(+) m6A 3'UTR//intron       22608085 chr4:75048913-75048914(+) m6A 3'UTR//intron       22608085 chr4:75048921-75048922(+) m6A 3'UTR//intron       22608085 chr4:75049272-75049273(+) m6A 3'UTR//intron       25456834 chr4:75049289-75049290(+) m6A 3'UTR//intron       25456834 chr4:75049333-75049334(+) m6A 3'UTR//intron       25456834 chr4:75049358-75049359(+) m6A 3'UTR//intron       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	MTHFD2L	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: MTHFD2L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).