Basic Information:

  VIRBase ID:  

HHID00012810

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          LDLRAD2:  NM_001013693     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	LDLRAD2
miRBase Accession/Entrez ID	MIMAT0004811	401944
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LDLRAD2	chr1:22144048(+) A-I      intronic chr1:22144056(+) A-I      intronic chr1:22143940(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LDLRAD2	chr1:22148722-22148723(+) m6A 3'UTR//exon       24284625//24981863//27773535//22575960 chr1:22148772-22148773(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960 chr1:22148778-22148779(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960 chr1:22148801-22148802(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22575960 chr1:22149157-22149158(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr1:22149297-22149298(+) m6A 3'UTR//intron       24284625//27773535 chr1:22149347-22149348(+) m6A 3'UTR//intron       24284625//27773535 chr1:22149377-22149378(+) m6A 3'UTR//intron       24284625//27773535 chr1:22149472-22149473(+) m6A 3'UTR//intron       24981863 chr1:22149518-22149519(+) m6A 3'UTR//intron       25456834//24981863//27371828 chr1:22149999-22150000(+) m6A 3'UTR//intron       27773536 chr1:22150196-22150197(+) m6A 3'UTR//intron       25456834 chr1:22150737-22150738(+) m6A 3'UTR       24284625 chr1:22150758-22150759(+) m6A 3'UTR       24284625 chr1:22150792-22150793(+) m6A 3'UTR       24284625 chr1:22150804-22150805(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	LDLRAD2	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: LDLRAD2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).