Detail Information

Basic Information:


  VIRBase ID:  

HHID00012801

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:           GDF6:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-33b-3p GDF6
miRBase
Accession/Entrez ID		 MIMAT0004811 392255
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BMP-13//BMP13//CDMP2//KFM//KFS//KFS1//KFSL//SGM1//SYNS4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-33b-3p
rs1014636340 chr17:17813869    C/T
rs1175344913 chr17:17813860    C/T
rs1212055173 chr17:17813859    G/C
rs1333766161 chr17:17813870    G/A
rs1359466877 chr17:17813864    A/G
rs751021350 chr17:17813857    G/A
rs1272832890 chr17:17813873    G/A
rs1296048342 chr17:17813872    G/A
rs1399118390 chr17:17813874    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GDF6
chr8:97156550-97156551(-) m6A 3'UTR       25456834
chr8:97156667-97156668(-) m6A 3'UTR       25456834
chr8:97156760-97156761(-) m6A 3'UTR       25456834//24981863
chr8:97156821-97156822(-) m6A 3'UTR//CDS       25456834//24981863
chr8:97156926-97156927(-) m6A CDS//intron       25456834//24981863
chr8:97156935-97156936(-) m6A CDS//intron       25456834//24981863
chr8:97157073-97157074(-) m6A CDS//intron       24981863
chr8:97157295-97157296(-) m6A CDS//intron       -
chr8:97157382-97157383(-) m6A CDS       -
chr8:97157405-97157406(-) m6A CDS//intron       -
chr8:97157550-97157551(-) m6A CDS       -
chr8:97157557-97157558(-) m6A CDS       -
chr8:97157688-97157689(-) m6A CDS       -
chr8:97172610-97172611(-) m6A CDS       -
chr8:97172698-97172699(-) m6A CDS       -
chr8:97172722-97172723(-) m6A CDS       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-33b-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
GDF6
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-33b-3p
Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-33b-3p
Interactor2: GDF6

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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