Basic Information:

  VIRBase ID:  

HHID00012769

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          DCBLD1:  NR_158983     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	DCBLD1
miRBase Accession/Entrez ID	MIMAT0004811	285761
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ94G16.1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCBLD1	chr6:117873178(+) A-I      intronic chr6:117873208(+) A-I      intronic chr6:117856100(+) A-I      intronic chr6:117873152(+) A-I      intronic chr6:117873160(+) A-I      intronic chr6:117873161(+) A-I      intronic chr6:117873168(+) A-I      intronic chr6:117873227(+) A-I      intronic chr6:117873047(+) A-I      intronic chr6:117873046(+) A-I      intronic chr6:117873019(+) A-I      intronic chr6:117873015(+) A-I      intronic chr6:117864669(+) A-I      intronic chr6:117858443(+) A-I      intronic chr6:117858442(+) A-I      intronic chr6:117850156(+) A-I      intronic chr6:117850027(+) A-I      intronic chr6:117837333(+) A-I      intronic chr6:117837329(+) A-I      intronic chr6:117837292(+) A-I      intronic chr6:117835512(+) A-I      intronic chr6:117820383(+) A-I      intronic chr6:117863302(+) A-I      intronic chr6:117805717(+) A-I      intronic chr6:117805678(+) A-I      intronic chr6:117805714(+) A-I      intronic chr6:117873233(+) A-I      intronic chr6:117873232(+) A-I      intronic chr6:117873228(+) A-I      intronic chr6:117864678(+) A-I      intronic chr6:117837403(+) A-I      intronic chr6:117835573(+) A-I      intronic chr6:117836322(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCBLD1	chr6:117824942-117824943(+) m6A CDS//exon       24209618//24981863//26404942 chr6:117824997-117824998(+) m6A CDS//exon       24209618//24981863//26404942//22608085 chr6:117825027-117825028(+) m6A CDS//exon       24981863//26404942//22608085 chr6:117825053-117825054(+) m6A CDS//exon       24981863//26404942//22608085 chr6:117825093-117825094(+) m6A CDS//exon       24981863//26404942 chr6:117866674-117866675(+) m6A 3'UTR//CDS//exon       24209618 chr6:117869101-117869102(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr6:117869138-117869139(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:117869346-117869347(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:117869405-117869406(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:117869438-117869439(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:117869555-117869556(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:117869602-117869603(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:117869750-117869751(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr6:117870081-117870082(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr6:117870129-117870130(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr6:117870237-117870238(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr6:117870249-117870250(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr6:117870478-117870479(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22608085 chr6:117870493-117870494(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:117870553-117870554(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:117870563-117870564(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:117870621-117870622(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:117870630-117870631(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:117870752-117870753(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	DCBLD1	Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: DCBLD1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).