Basic Information:

  VIRBase ID:  

HHID00012762

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          CYB561D1:  NM_182580     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	CYB561D1
miRBase Accession/Entrez ID	MIMAT0004811	284613
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CYB561D1	chr1:110037283(+) A-I      intronic chr1:110037380(+) A-I      intronic chr1:110037298(+) A-I      intronic chr1:110037282(+) A-I      intronic chr1:110037281(+) A-I      intronic chr1:110042249(+) A-I      3'UTR chr1:110042169(+) A-I      3'UTR chr1:110037348(+) A-I      intronic chr1:110042047(+) A-I      3'UTR chr1:110037487(+) A-I      intronic chr1:110042018(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CYB561D1	chr1:110036708-110036709(+) m6A 5'UTR       24981863 chr1:110036811-110036812(+) m6A CDS//intron       24981863 chr1:110038421-110038422(+) m6A 3'UTR//CDS       - chr1:110038482-110038483(+) m6A 3'UTR//CDS       25456834//24981863 chr1:110038536-110038537(+) m6A 3'UTR//CDS       25456834//24981863//22608085 chr1:110038700-110038701(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr1:110038922-110038923(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr1:110039002-110039003(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr1:110039011-110039012(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr1:110039123-110039124(+) m6A 3'UTR//intron       24209618//24981863 chr1:110042121-110042122(+) m6A 3'UTR//intron       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CYB561D1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: CYB561D1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).