Basic Information:

  VIRBase ID:  

HHID00012760

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          PPP1R37:  NM_019121     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	PPP1R37
miRBase Accession/Entrez ID	MIMAT0004811	284352
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LRRC68

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PPP1R37	chr19:45612000(+) A-I      ncRNA chr19:45611993(+) A-I      ncRNA chr19:45612172(+) A-I      ncRNA chr19:45632740(+) A-I      intronic chr19:45632737(+) A-I      intronic chr19:45632686(+) A-I      intronic chr19:45632746(+) A-I      intronic chr19:45612065(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PPP1R37	chr19:45610296(+) A-I intron -    22327324 chr19:45637957(+) A-I intron -    22327324 chr19:45638386(+) A-I intron -    22327324 chr19:45597730(+) A-G intron -    22484847 chr19:45598530(+) A-G intron -    22484847 chr19:45610622(+) A-G intron -    22484847 chr19:45610710(+) A-G intron -    22484847 chr19:45610804(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPP1R37	chr19:45596516-45596517(+) m6A 5'UTR//exon       24209618//25456834//24981863//27773536//22608085 chr19:45596526-45596527(+) m6A 5'UTR//exon       24209618//25456834//24981863//27773536//22608085 chr19:45641831-45641832(+) m6A CDS//exon//intron       - chr19:45643503-45643504(+) m6A CDS//exon//intron       - chr19:45643530-45643531(+) m6A CDS//exon//intron       - chr19:45643783-45643784(+) m6A CDS//exon       - chr19:45645364-45645365(+) m6A CDS//exon       24284625 chr19:45645578-45645579(+) m6A CDS//exon       24284625 chr19:45645584-45645585(+) m6A CDS//exon       24284625 chr19:45645608-45645609(+) m6A CDS//exon       24284625 chr19:45645795-45645796(+) m6A exon//intron       24981863 chr19:45645801-45645802(+) m6A exon//intron       24981863 chr19:45645812-45645813(+) m6A exon//intron       24981863 chr19:45645852-45645853(+) m6A exon//intron       24981863 chr19:45645856-45645857(+) m6A exon//intron       25456834 chr19:45645867-45645868(+) m6A exon//intron       25456834//24981863 chr19:45645892-45645893(+) m6A exon//intron       25456834//24981863 chr19:45645963-45645964(+) m6A exon//intron       25456834//24981863 chr19:45646083-45646084(+) m6A exon//intron       - chr19:45646133-45646134(+) m6A exon//intron       - chr19:45646167-45646168(+) m6A exon//intron       - chr19:45646844-45646845(+) m6A CDS//exon       24284625 chr19:45648428-45648429(+) m6A CDS//exon       - chr19:45648468-45648469(+) m6A CDS//exon       - chr19:45648489-45648490(+) m6A CDS//exon       - chr19:45648502-45648503(+) m6A CDS//exon       - chr19:45648742-45648743(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr19:45648824-45648825(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr19:45648830-45648831(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr19:45648836-45648837(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr19:45648842-45648843(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr19:45648889-45648890(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr19:45648920-45648921(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45648938-45648939(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:45649154-45649155(+) m6A CDS//exon       24284625//25456834 chr19:45649648-45649649(+) m6A CDS//exon       24981863 chr19:45649721-45649722(+) m6A CDS//exon       24284625//24981863 chr19:45650045-45650046(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085 chr19:45650099-45650100(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:45650257-45650258(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863 chr19:45650267-45650268(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863 chr19:45650379-45650380(+) m6A 3'UTR//exon       24284625//24209618 chr19:45650522-45650523(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PPP1R37	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: PPP1R37

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).