Detail Information

Basic Information:


  VIRBase ID:  

HHID00012757

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:           ADGRF1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-33b-3p ADGRF1
miRBase
Accession/Entrez ID		 MIMAT0004811 266977
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GPR110//hGPCR36//KPG_012//PGR19

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-33b-3p
rs1014636340 chr17:17813869    C/T
rs1175344913 chr17:17813860    C/T
rs1212055173 chr17:17813859    G/C
rs1333766161 chr17:17813870    G/A
rs1359466877 chr17:17813864    A/G
rs751021350 chr17:17813857    G/A
rs1272832890 chr17:17813873    G/A
rs1296048342 chr17:17813872    G/A
rs1399118390 chr17:17813874    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ADGRF1
chr6:46990610(-) A-I      intronic
chr6:46990584(-) A-I      intronic
chr6:46988149(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADGRF1
chr6:46976897-46976898(-) m6A CDS//exon       27773535
chr6:46976944-46976945(-) m6A CDS//exon       27773535
chr6:46977215-46977216(-) m6A CDS//exon       27773535
chr6:46977227-46977228(-) m6A CDS//exon       27773535
chr6:46977284-46977285(-) m6A CDS//exon       27773535
chr6:46977315-46977316(-) m6A CDS//exon       27773535
chr6:46977587-46977588(-) m6A CDS//exon       27773535
chr6:46977635-46977636(-) m6A CDS//exon       27773535
chr6:46977661-46977662(-) m6A CDS//exon       27773535
chr6:46977704-46977705(-) m6A CDS//exon       27773535
chr6:46977738-46977739(-) m6A CDS//exon       27773535
chr6:46977764-46977765(-) m6A CDS//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-33b-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ADGRF1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-33b-3p
Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-33b-3p
Interactor2: ADGRF1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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