Basic Information:

  VIRBase ID:  

HHID00012742

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          PXT1:  NM_152990     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	PXT1
miRBase Accession/Entrez ID	MIMAT0004811	222659
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	STEPP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PXT1	chr6:36397421(-) A-I      intronic chr6:36397420(-) A-I      intronic chr6:36397875(-) A-I      intronic chr6:36397876(-) A-I      intronic chr6:36397897(-) A-I      intronic chr6:36408350(-) A-I      intronic chr6:36407295(-) A-I      intronic chr6:36397902(-) A-I      intronic chr6:36407209(-) A-I      intronic chr6:36407252(-) A-I      intronic chr6:36407241(-) A-I      intronic chr6:36407226(-) A-I      intronic chr6:36407223(-) A-I      intronic chr6:36406395(-) A-I      intronic chr6:36396996(-) A-I      intronic chr6:36397407(-) A-I      intronic chr6:36397470(-) A-I      intronic chr6:36397464(-) A-I      intronic chr6:36397458(-) A-I      intronic chr6:36397455(-) A-I      intronic chr6:36397447(-) A-I      intronic chr6:36371430(-) A-I      intronic chr6:36379994(-) A-I      intronic chr6:36371453(-) A-I      intronic chr6:36362819(-) A-I      intronic chr6:36361384(-) A-I      intronic chr6:36379980(-) A-I      intronic chr6:36379981(-) A-I      intronic chr6:36405455(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PXT1	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: PXT1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).