Basic Information:

  VIRBase ID:  

HHID00012637

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          ZCCHC3:  NM_033089     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	ZCCHC3
miRBase Accession/Entrez ID	MIMAT0004811	85364
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf99

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZCCHC3	chr20:278137-278138(+) m6A 5'UTR       25456834//24981863 chr20:278142-278143(+) m6A 5'UTR       25456834//24981863 chr20:278377-278378(+) m1A CDS       26863196//26863410 chr20:278480-278481(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr20:278555-278556(+) m6A CDS       24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr20:278599-278600(+) m1A CDS       26863196 chr20:278774-278775(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:278816-278817(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:278939-278940(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:278951-278952(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:279032-279033(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:279109-279110(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:279229-279230(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:279253-279254(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:279281-279282(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:279366-279367(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr20:279442-279443(+) m6A 3'UTR       24284625//24209618//24981863 chr20:279466-279467(+) m6A 3'UTR       24284625//24209618//24981863 chr20:279500-279501(+) m6A 3'UTR       24284625//24981863//26404942 chr20:279512-279513(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279549-279550(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279560-279561(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279582-279583(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279648-279649(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279892-279893(+) m6A 3'UTR       24284625//24981863//22608085 chr20:279996-279997(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280083-280084(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280162-280163(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280180-280181(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280209-280210(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280481-280482(+) m6A 3'UTR       24284625//26404942 chr20:280488-280489(+) m6A 3'UTR       24284625//26404942 chr20:280667-280668(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ZCCHC3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: ZCCHC3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).