Basic Information:

  VIRBase ID:  

HHID00012627

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          TMEM101:  NM_001304813     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	TMEM101
miRBase Accession/Entrez ID	MIMAT0004811	84336
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM101	chr17:42088717-42088718(-) m6A 3'UTR       27773535 chr17:42088758-42088759(-) m6A 3'UTR       27773535 chr17:42088868-42088869(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828 chr17:42088908-42088909(-) m6A 3'UTR       24209618//24981863//27773535//27371828 chr17:42088964-42088965(-) m6A 3'UTR       24209618//24981863//27773535 chr17:42089324-42089325(-) m6A CDS       25456834//24981863 chr17:42089365-42089366(-) m6A CDS       25456834//24981863 chr17:42092476-42092477(-) m6A 5'UTR       25456834 chr17:42092520-42092521(-) m6A 5'UTR       25456834 chr17:42101063-42101064(-) m6A exon       25456834//27773536//22608085 chr17:42101149-42101150(-) m6A exon       25456834//24981863//27773536//22608085 chr17:42101214-42101215(-) m6A exon       25456834//24981863//27773536//22608085 chr17:42101253-42101254(-) m6A exon       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TMEM101	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: TMEM101

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).