Basic Information:

  VIRBase ID:  

HHID00012537

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          STRIP2:  NM_001134336     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	STRIP2
miRBase Accession/Entrez ID	MIMAT0004811	57464
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM40B//FAR11B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STRIP2	chr7:129081430(+) A-I      intronic chr7:129121071(+) A-I      intronic chr7:129119448(+) A-I      intronic chr7:129081643(+) A-I      intronic chr7:129081799(+) A-I      intronic chr7:129081968(+) A-I      intronic chr7:129122441(+) A-I      intronic chr7:129081648(+) A-I      intronic chr7:129082951(+) A-I      intronic chr7:129118914(+) A-I      intronic chr7:129118926(+) A-I      intronic chr7:129119431(+) A-I      intronic chr7:129127972(+) A-I      3'UTR chr7:129127045(+) A-I      3'UTR chr7:129127042(+) A-I      3'UTR chr7:129127036(+) A-I      3'UTR chr7:129126994(+) A-I      3'UTR chr7:129127992(+) A-I      3'UTR chr7:129126877(+) A-I      3'UTR chr7:129081813(+) A-I      intronic chr7:129114115(+) A-I      intronic chr7:129119099(+) A-I      intronic chr7:129127061(+) A-I      3'UTR chr7:129126911(+) A-I      3'UTR chr7:129127987(+) A-I      3'UTR chr7:129081837(+) A-I      intronic chr7:129118272(+) A-I      intronic chr7:129123719(+) A-I      intronic chr7:129118286(+) A-I      intronic chr7:129118915(+) A-I      intronic chr7:129083133(+) A-I      intronic chr7:129081814(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STRIP2	chr7:129074285-129074286(+) m6A 5'UTR       25456834//24981863 chr7:129074320-129074321(+) m6A CDS       25456834//24981863 chr7:129074337-129074338(+) m6A CDS       25456834//24981863 chr7:129079872-129079873(+) m6A CDS       24981863 chr7:129083885-129083886(+) m6A CDS       24209618 chr7:129098074-129098075(+) m6A CDS       24284625 chr7:129098083-129098084(+) m6A CDS//exon       24284625 chr7:129098112-129098113(+) m6A CDS//exon       24284625 chr7:129122823-129122824(+) m6A CDS       - chr7:129125432-129125433(+) m6A CDS       24284625//24981863//22608085 chr7:129125440-129125441(+) m6A CDS       24284625//24981863//22608085 chr7:129125507-129125508(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr7:129125515-129125516(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr7:129125718-129125719(+) m6A 3'UTR       24284625//24981863//22608085 chr7:129125899-129125900(+) m6A 3'UTR       - chr7:129125916-129125917(+) m6A 3'UTR       - chr7:129125954-129125955(+) m6A 3'UTR       - chr7:129126081-129126082(+) m6A 3'UTR       24981863 chr7:129126102-129126103(+) m6A 3'UTR       24981863 chr7:129127077-129127078(+) m6A 3'UTR       - chr7:129128115-129128116(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	STRIP2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: STRIP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).