Detail Information

Basic Information:


  VIRBase ID:  

HHID00012457

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:           EXOSC1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-33b-3p EXOSC1
miRBase
Accession/Entrez ID		 MIMAT0004811 51013
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-108//CSL4//Csl4p//p13//SKI4//Ski4p

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-33b-3p
rs1014636340 chr17:17813869    C/T
rs1175344913 chr17:17813860    C/T
rs1212055173 chr17:17813859    G/C
rs1333766161 chr17:17813870    G/A
rs1359466877 chr17:17813864    A/G
rs751021350 chr17:17813857    G/A
rs1272832890 chr17:17813873    G/A
rs1296048342 chr17:17813872    G/A
rs1399118390 chr17:17813874    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EXOSC1
chr10:99197947(-) A-I      intronic
chr10:99203618(-) A-I      ncRNA
chr10:99203592(-) A-I      ncRNA
chr10:99203626(-) A-I      ncRNA
chr10:99201364(-) A-I      intronic
chr10:99196598(-) A-I      intronic
chr10:99201888(-) A-I      intronic
chr10:99196641(-) A-I      intronic
chr10:99201340(-) A-I      intronic
chr10:99196711(-) A-I      intronic
chr10:99201913(-) A-I      intronic
chr10:99201404(-) A-I      intronic
chr10:99201909(-) A-I      intronic
chr10:99201313(-) A-I      intronic
chr10:99196624(-) A-I      intronic
chr10:99202543(-) A-I      intronic
chr10:99201350(-) A-I      intronic
chr10:99202784(-) A-I      intronic
chr10:99201316(-) A-I      intronic
chr10:99200390(-) A-I      intronic
chr10:99197356(-) A-I      intronic
chr10:99198585(-) A-I      intronic
chr10:99202617(-) A-I      intronic
chr10:99201716(-) A-I      intronic
chr10:99197269(-) A-I      intronic
chr10:99201891(-) A-I      intronic
chr10:99202631(-) A-I      intronic
chr10:99197737(-) A-I      intronic
chr10:99201771(-) A-I      intronic
chr10:99201768(-) A-I      intronic
chr10:99196759(-) A-I      intronic
chr10:99196704(-) A-I      intronic
chr10:99196632(-) A-I      intronic
chr10:99200413(-) A-I      intronic
chr10:99196618(-) A-I      intronic
chr10:99196609(-) A-I      intronic
chr10:99201785(-) A-I      intronic
chr10:99195683(-) A-I      3'UTR
chr10:99203665(-) A-I      ncRNA
chr10:99196735(-) A-I      intronic
chr10:99202380(-) A-I      intronic
chr10:99197946(-) A-I      intronic
chr10:99196672(-) A-I      intronic
chr10:99202535(-) A-I      intronic
chr10:99196686(-) A-I      intronic
chr10:99201851(-) A-I      intronic
chr10:99200123(-) A-I      intronic
chr10:99196673(-) A-I      intronic
chr10:99196633(-) A-I      intronic
chr10:99202546(-) A-I      intronic
chr10:99196524(-) A-I      intronic
chr10:99196659(-) A-I      intronic
chr10:99203295(-) A-I      intronic
chr10:99196713(-) A-I      intronic
chr10:99202690(-) A-I      intronic
chr10:99202616(-) A-I      intronic
chr10:99202801(-) A-I      intronic
chr10:99201412(-) A-I      intronic
chr10:99202597(-) A-I      intronic
chr10:99201786(-) A-I      intronic
chr10:99201766(-) A-I      intronic
chr10:99203313(-) A-I      intronic
chr10:99201812(-) A-I      intronic
chr10:99201878(-) A-I      intronic
chr10:99203322(-) A-I      intronic
chr10:99202549(-) A-I      intronic
chr10:99201450(-) A-I      intronic
chr10:99201372(-) A-I      intronic
chr10:99198646(-) A-I      intronic
chr10:99202575(-) A-I      intronic
chr10:99201852(-) A-I      intronic
chr10:99196687(-) A-I      intronic
chr10:99201440(-) A-I      intronic
chr10:99201742(-) A-I      intronic
chr10:99201929(-) A-I      intronic
chr10:99196669(-) A-I      intronic
chr10:99202809(-) A-I      intronic
chr10:99202799(-) A-I      intronic
chr10:99202534(-) A-I      intronic
chr10:99202358(-) A-I      intronic
chr10:99202314(-) A-I      intronic
chr10:99202566(-) A-I      intronic
chr10:99201822(-) A-I      intronic
chr10:99201118(-) A-I      intronic
chr10:99201121(-) A-I      intronic
chr10:99196577(-) A-I      intronic
chr10:99201385(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED EXOSC1
chr10:99196641(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EXOSC1
chr10:99195915-99195916(-) m6A 3'UTR       27773535
chr10:99195984-99195985(-) m6A 3'UTR       27773535
chr10:99195989-99195990(-) m6A 3'UTR       27773535
chr10:99203892-99203893(-) m6A exon//intron       27773535
chr10:99203956-99203957(-) m6A exon//intron       27773535
chr10:99203988-99203989(-) m6A exon//intron       27773535
chr10:99204101-99204102(-) m6A exon//intron       27773535
chr10:99204247-99204248(-) m6A exon//intron       27773535
chr10:99204262-99204263(-) m6A exon//intron       27773535
chr10:99204823-99204824(-) m6A exon//intron       27773535
chr10:99204834-99204835(-) m6A exon//intron       27773535
chr10:99204894-99204895(-) m6A exon//intron       27773535
chr10:99205753-99205754(-) m6A 5'UTR//CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-33b-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
EXOSC1
Cytosol K562 cells     -
Exosome Blood     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-33b-3p
Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-33b-3p
Interactor2: EXOSC1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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