Basic Information:

  VIRBase ID:  

HHID00012450

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          TIMM22:  NM_013337     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	TIMM22
miRBase Accession/Entrez ID	MIMAT0004811	29928
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COXPD43//TEX4//TIM22

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TIMM22	chr17:903219(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TIMM22	chr17:902129-902130(+) m6A CDS       22575960 chr17:902760-902761(+) m6A CDS       24284625//24209618 chr17:902767-902768(+) m6A CDS       24284625//24209618 chr17:902776-902777(+) m6A CDS       24284625//24209618 chr17:904387-904388(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:904430-904431(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:904524-904525(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr17:904573-904574(+) Cm 3'UTR       - chr17:904584-904585(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:904721-904722(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:904767-904768(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr17:905017-905018(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr17:905115-905116(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr17:905178-905179(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr17:906201-906202(+) m6A 3'UTR       24209618//24981863//22608085 chr17:906206-906207(+) m6A 3'UTR       24209618//24981863//22608085 chr17:906222-906223(+) m6A 3'UTR       24209618//24981863//22608085 chr17:906248-906249(+) m6A 3'UTR       24209618//24981863//22608085 chr17:906329-906330(+) m6A 3'UTR       24981863//22608085 chr17:906356-906357(+) m6A 3'UTR       24284625//24981863//22608085 chr17:906442-906443(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr17:906485-906486(+) m6A 3'UTR       24284625//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TIMM22	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: TIMM22

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).