Basic Information:

  VIRBase ID:  

HHID00012344

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          WSCD2:  NM_014653     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	WSCD2
miRBase Accession/Entrez ID	MIMAT0004811	9671
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WSCD2	chr12:108568635(+) A-I      intronic chr12:108615254(+) A-I      intronic chr12:108541541(+) A-I      intronic chr12:108626046(+) A-I      intronic chr12:108634707(+) A-I      intronic chr12:108615283(+) A-I      intronic chr12:108635043(+) A-I      intronic chr12:108635251(+) A-I      intronic chr12:108635211(+) A-I      intronic chr12:108635280(+) A-I      intronic chr12:108634689(+) A-I      intronic chr12:108637034(+) A-I      intronic chr12:108615104(+) A-I      intronic chr12:108573790(+) A-I      intronic chr12:108560746(+) A-I      intronic chr12:108635265(+) A-I      intronic chr12:108635721(+) A-I      intronic chr12:108634610(+) A-I      intronic chr12:108634594(+) A-I      intronic chr12:108615213(+) A-I      intronic chr12:108615076(+) A-I      intronic chr12:108615277(+) A-I      intronic chr12:108635697(+) A-I      intronic chr12:108638428(+) A-I      intronic chr12:108634747(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WSCD2	chr12:108589164-108589165(+) m6A 5'UTR//exon//intron       - chr12:108589229-108589230(+) m6A 5'UTR//exon//intron       25456834//24981863 chr12:108589255-108589256(+) m6A 5'UTR//exon//intron       25456834//24981863 chr12:108589291-108589292(+) m6A 5'UTR//exon//intron       25456834//24981863 chr12:108589308-108589309(+) m6A 5'UTR//exon//intron       25456834 chr12:108589328-108589329(+) m6A 5'UTR//exon//intron       25456834 chr12:108589357-108589358(+) m6A 5'UTR//exon//intron       25456834 chr12:108589444-108589445(+) m6A 5'UTR//exon//intron       25456834 chr12:108589494-108589495(+) m6A 5'UTR//intron       25456834 chr12:108589501-108589502(+) m6A 5'UTR//intron       25456834 chr12:108589538-108589539(+) m6A 5'UTR//intron       25456834 chr12:108589751-108589752(+) m6A CDS//intron       25456834 chr12:108589760-108589761(+) m6A CDS//intron       25456834 chr12:108589841-108589842(+) m6A CDS//intron       25456834 chr12:108589878-108589879(+) m6A CDS//intron       25456834 chr12:108590088-108590089(+) m6A exon//intron       25456834 chr12:108641788-108641789(+) m6A CDS       25456834 chr12:108641821-108641822(+) m6A CDS       25456834 chr12:108641866-108641867(+) m6A CDS       25456834 chr12:108641878-108641879(+) m6A CDS       25456834 chr12:108641935-108641936(+) m6A CDS       25456834 chr12:108642022-108642023(+) m6A CDS       25456834//22575960 chr12:108642033-108642034(+) m6A CDS       25456834//22575960 chr12:108642082-108642083(+) m6A CDS       25456834 chr12:108642144-108642145(+) m6A 3'UTR       25456834//22575960 chr12:108642175-108642176(+) m6A 3'UTR       25456834 chr12:108642182-108642183(+) m6A 3'UTR       25456834 chr12:108642226-108642227(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	WSCD2	Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: WSCD2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).