Detail Information

Basic Information:


  VIRBase ID:  

HHID00012292

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:           LRP8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-33b-3p LRP8
miRBase
Accession/Entrez ID		 MIMAT0004811 7804
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - APOER2//HSZ75190//LRP-8//MCI1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-33b-3p
rs1014636340 chr17:17813869    C/T
rs1175344913 chr17:17813860    C/T
rs1212055173 chr17:17813859    G/C
rs1333766161 chr17:17813870    G/A
rs1359466877 chr17:17813864    A/G
rs751021350 chr17:17813857    G/A
rs1272832890 chr17:17813873    G/A
rs1296048342 chr17:17813872    G/A
rs1399118390 chr17:17813874    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRP8
chr1:53767666(-) A-I      intronic
chr1:53768294(-) A-I      intronic
chr1:53768346(-) A-I      intronic
chr1:53768353(-) A-I      intronic
chr1:53712524(-) A-I      3'UTR
chr1:53767614(-) A-I      intronic
chr1:53767522(-) A-I      intronic
chr1:53767402(-) A-I      intronic
chr1:53767397(-) A-I      intronic
chr1:53767320(-) A-I      intronic
chr1:53717450(-) A-I      intronic
chr1:53717459(-) A-I      intronic
chr1:53768482(-) A-I      intronic
chr1:53728625(-) A-I      intronic
chr1:53767291(-) A-I      intronic
chr1:53789871(-) A-I      intronic
chr1:53714222(-) A-I      intronic
chr1:53712950(-) A-I      intronic
chr1:53767505(-) A-I      intronic
chr1:53767680(-) A-I      intronic
chr1:53713182(-) A-I      intronic
chr1:53735082(-) A-I      intronic
chr1:53767444(-) A-I      intronic
chr1:53789874(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LRP8
chr1:53712950(-) A-G intron -    22484847
chr1:53717972(-) G-A intron -    22484847
chr1:53732972(-) A-G intron -    22484847
chr1:53733060(-) A-G intron -    22484847
chr1:53733156(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRP8
chr1:53708443-53708444(-) m6A 3'UTR       27773535
chr1:53708461-53708462(-) m6A 3'UTR       27773535
chr1:53708474-53708475(-) m6A 3'UTR       27773535
chr1:53709142-53709143(-) m6A 3'UTR       24981863//27773535
chr1:53709314-53709315(-) m6A 3'UTR       24981863//27773535
chr1:53709347-53709348(-) m6A 3'UTR       24981863//27773535
chr1:53709373-53709374(-) m6A 3'UTR       24981863//27773535
chr1:53709388-53709389(-) m6A 3'UTR       27773535
chr1:53709394-53709395(-) m6A 3'UTR       27773535
chr1:53709538-53709539(-) m6A 3'UTR       27773535
chr1:53709649-53709650(-) m6A 3'UTR       27773535
chr1:53709771-53709772(-) m6A 3'UTR       24981863//27773535//22608085
chr1:53709811-53709812(-) m6A 3'UTR       24981863//27773535//22608085
chr1:53709825-53709826(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53709899-53709900(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53709911-53709912(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53709930-53709931(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:53710003-53710004(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:53710030-53710031(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:53710165-53710166(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53710212-53710213(-) m6A 3'UTR       -
chr1:53710285-53710286(-) m6A 3'UTR       -
chr1:53710339-53710340(-) m6A 3'UTR       -
chr1:53710391-53710392(-) m6A 3'UTR       -
chr1:53710444-53710445(-) m6A 3'UTR       -
chr1:53710476-53710477(-) m6A 3'UTR       -
chr1:53710495-53710496(-) m6A 3'UTR       -
chr1:53710596-53710597(-) m6A 3'UTR       -
chr1:53710610-53710611(-) m6A 3'UTR       -
chr1:53710659-53710660(-) m6A 3'UTR       -
chr1:53710753-53710754(-) m6A 3'UTR       -
chr1:53711225-53711226(-) m6A 3'UTR       27773535
chr1:53711345-53711346(-) m6A 3'UTR       27773535
chr1:53711368-53711369(-) m6A 3'UTR       -
chr1:53716390-53716391(-) m6A 3'UTR//CDS       24981863
chr1:53716432-53716433(-) m6A 3'UTR//CDS       24981863//27773535
chr1:53716473-53716474(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:53716488-53716489(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:53720844-53720845(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:53723016-53723017(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535
chr1:53723030-53723031(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr1:53723058-53723059(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr1:53723088-53723089(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr1:53723702-53723703(-) m6A exon//intron       24981863//27773535
chr1:53723716-53723717(-) m6A exon//intron       27773535
chr1:53724010-53724011(-) m6A 3'UTR//CDS//exon       27773535
chr1:53730056-53730057(-) m6A 3'UTR//CDS//exon       27773535
chr1:53732249-53732250(-) m6A 3'UTR//5'UTR//CDS//exon       27773535
chr1:53733619-53733620(-) m6A exon//intron       -
chr1:53736806-53736807(-) m6A 3'UTR//CDS//intron       27773535//22575960
chr1:53736907-53736908(-) m6A 3'UTR//5'UTR//CDS       27773535//22575960
chr1:53736915-53736916(-) m6A 3'UTR//5'UTR//CDS       27773535//22575960
chr1:53741340-53741341(-) m6A 5'UTR//CDS//intron       24209618
chr1:53741380-53741381(-) m6A 5'UTR//CDS//intron       24209618
chr1:53742386-53742387(-) m6A CDS//intron       24209618
chr1:53742539-53742540(-) m6A CDS//intron       24209618//27773536
chr1:53793068-53793069(-) m6A 5'UTR//intron       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-33b-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
LRP8
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-33b-3p
Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-33b-3p
Interactor2: LRP8

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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