Basic Information:

  VIRBase ID:  

HHID00012264

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          SYT1:  NM_001135806     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	SYT1
miRBase Accession/Entrez ID	MIMAT0004811	6857
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BAGOS//P65//SVP65//SYT

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SYT1	chr12:79526046(+) A-I      intronic chr12:79526033(+) A-I      intronic chr12:79550309(+) A-I      intronic chr12:79526076(+) A-I      intronic chr12:79526073(+) A-I      intronic chr12:79521972(+) A-I      intronic chr12:79521990(+) A-I      intronic chr12:79522012(+) A-I      intronic chr12:79521993(+) A-I      intronic chr12:79522013(+) A-I      intronic chr12:79522014(+) A-I      intronic chr12:79521992(+) A-I      intronic chr12:79340233(+) A-I      intronic chr12:79340202(+) A-I      intronic chr12:79634771(+) A-I      intronic chr12:79634691(+) A-I      intronic chr12:79340225(+) A-I      intronic chr12:79554922(+) A-I      intronic chr12:79526078(+) A-I      intronic chr12:79526077(+) A-I      intronic chr12:79634832(+) A-I      intronic chr12:79634882(+) A-I      intronic chr12:79466907(+) A-I      intronic chr12:79521917(+) A-I      intronic chr12:79519122(+) A-I      intronic chr12:79526082(+) A-I      intronic chr12:79667152(+) A-I      intronic chr12:79470466(+) A-I      intronic chr12:79355169(+) A-I      intronic chr12:79833732(+) A-I      intronic chr12:79634878(+) A-I      intronic chr12:79639057(+) A-I      intronic chr12:79470459(+) A-I      intronic chr12:79738345(+) A-I      intronic chr12:79782219(+) A-I      intronic chr12:79634892(+) A-I      intronic chr12:79826474(+) A-I      intronic chr12:79552416(+) A-I      intronic chr12:79789405(+) A-I      intronic chr12:79459067(+) A-I      intronic chr12:79573383(+) A-I      intronic chr12:79467021(+) A-I      intronic chr12:79459030(+) A-I      intronic chr12:79552592(+) A-I      intronic chr12:79459056(+) A-I      intronic chr12:79835213(+) A-I      intronic chr12:79519209(+) A-I      intronic chr12:79570019(+) A-I      intronic chr12:79570020(+) A-I      intronic chr12:79763109(+) A-I      intronic chr12:79609348(+) A-I      intronic chr12:79519250(+) A-I      intronic chr12:79520170(+) A-I      intronic chr12:79521911(+) A-I      intronic chr12:79634744(+) A-I      intronic chr12:79609462(+) A-I      intronic chr12:79639196(+) A-I      intronic chr12:79609418(+) A-I      intronic chr12:79670300(+) A-I      intronic chr12:79763153(+) A-I      intronic chr12:79552556(+) A-I      intronic chr12:79635216(+) A-I      intronic chr12:79635131(+) A-I      intronic chr12:79552423(+) A-I      intronic chr12:79667655(+) A-I      intronic chr12:79514585(+) A-I      intronic chr12:79618599(+) A-I      intronic chr12:79670367(+) A-I      intronic chr12:79634682(+) A-I      intronic chr12:79475191(+) A-I      intronic chr12:79824405(+) A-I      intronic chr12:79340324(+) A-I      intronic chr12:79702049(+) A-I      intronic chr12:79651397(+) A-I      intronic chr12:79340315(+) A-I      intronic chr12:79466999(+) A-I      intronic chr12:79481762(+) A-I      intronic chr12:79327880(+) A-I      intronic chr12:79459061(+) A-I      intronic chr12:79522479(+) A-I      intronic chr12:79322295(+) A-I      intronic chr12:79667155(+) A-I      intronic chr12:79475340(+) A-I      intronic chr12:79573381(+) A-I      intronic chr12:79653453(+) A-I      intronic chr12:79354994(+) A-I      intronic chr12:79520202(+) A-I      intronic chr12:79323051(+) A-I      intronic chr12:79634900(+) A-I      intronic chr12:79667717(+) A-I      intronic chr12:79519260(+) A-I      intronic chr12:79835282(+) A-I      intronic chr12:79774314(+) A-I      intronic chr12:79835280(+) A-I      intronic chr12:79323124(+) A-I      intronic chr12:79522098(+) A-I      intronic chr12:79407850(+) A-I      intronic chr12:79519357(+) A-I      intronic chr12:79519150(+) A-I      intronic chr12:79552436(+) A-I      intronic chr12:79763127(+) A-I      intronic chr12:79590457(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SYT1	chr12:79258537-79258538(+) m6A 5'UTR//intron       24981863 chr12:79441080-79441081(+) m6A 5'UTR//exon//intron       24981863 chr12:79441105-79441106(+) m6A 5'UTR//exon//intron       24981863 chr12:79441115-79441116(+) m6A 5'UTR//exon//intron       24981863 chr12:79441139-79441140(+) m6A 5'UTR//exon//intron       24981863 chr12:79496801-79496802(+) m6A 5'UTR//intron       24981863 chr12:79679665-79679666(+) m6A CDS       24981863//27773535 chr12:79679725-79679726(+) m6A CDS       24981863//27773535 chr12:79685811-79685812(+) m6A CDS//exon       24981863//27773535 chr12:79685843-79685844(+) m6A CDS//exon       24981863 chr12:79685861-79685862(+) m6A CDS//exon       24981863 chr12:79685870-79685871(+) m6A CDS//exon       24981863 chr12:79837976-79837977(+) m6A CDS       24981863 chr12:79842725-79842726(+) m6A CDS       24981863 chr12:79842812-79842813(+) m6A CDS       24981863 chr12:79843650-79843651(+) m6A 3'UTR       24981863//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SYT1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: SYT1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).