Basic Information:

  VIRBase ID:  

HHID00012253

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-33b-3p:  MIMAT0004811          SRSF3:  NR_036610     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-33b-3p	SRSF3
miRBase Accession/Entrez ID	MIMAT0004811	6428
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SFRS3//SRp20

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-33b-3p	rs1014636340 chr17:17813869    C/T rs1175344913 chr17:17813860    C/T rs1212055173 chr17:17813859    G/C rs1333766161 chr17:17813870    G/A rs1359466877 chr17:17813864    A/G rs751021350 chr17:17813857    G/A rs1272832890 chr17:17813873    G/A rs1296048342 chr17:17813872    G/A rs1399118390 chr17:17813874    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SRSF3	chr6:36563776(+) A-I      intronic chr6:36565707(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SRSF3	chr6:36564896(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SRSF3	chr6:36562205-36562206(+) m6A 5'UTR//exon       24284625//25456834//24981863//27773535 chr6:36564564-36564565(+) m6A CDS//exon       27773535 chr6:36564594-36564595(+) m6A CDS//exon       27773535 chr6:36564640-36564641(+) m6A CDS//exon       22575960 chr6:36564669-36564670(+) m6A CDS//exon       22575960 chr6:36564735-36564736(+) Tm CDS//exon       - chr6:36566655-36566656(+) m6A 3'UTR//CDS//exon       22575960 chr6:36567974-36567975(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535 chr6:36569769-36569770(+) m6A 3'UTR//exon       27773535 chr6:36569849-36569850(+) m6A 3'UTR//exon       27773535 chr6:36569911-36569912(+) m6A 3'UTR//exon       27773535 chr6:36570024-36570025(+) m6A 3'UTR//exon       27773535 chr6:36570042-36570043(+) m6A 3'UTR//exon       27773535 chr6:36570053-36570054(+) m6A 3'UTR//exon       27773535 chr6:36570061-36570062(+) m6A 3'UTR//exon       27773535 chr6:36570178-36570179(+) m6A 3'UTR//exon       26404942 chr6:36570195-36570196(+) m6A 3'UTR//exon       26404942 chr6:36570206-36570207(+) m6A 3'UTR//exon       26404942 chr6:36570943-36570944(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-33b-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SRSF3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-33b-3p	Cisplatin 5702198       27559850

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-33b-3p
Interactor2: SRSF3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).