Basic Information:

  VIRBase ID:  

HHID00012059

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          ZBTB34:  NM_001099270     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	ZBTB34
miRBase Accession/Entrez ID	MIMAT0004593	403341
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF918

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZBTB34	chr9:129640128(+) A-I      intronic chr9:129641225(+) A-I      intronic chr9:129641238(+) A-I      intronic chr9:129633742(+) A-I      intronic chr9:129633741(+) A-I      intronic chr9:129636045(+) A-I      intronic chr9:129641223(+) A-I      intronic chr9:129640704(+) A-I      intronic chr9:129640694(+) A-I      intronic chr9:129640690(+) A-I      intronic chr9:129633746(+) A-I      intronic chr9:129640494(+) A-I      intronic chr9:129634365(+) A-I      intronic chr9:129640539(+) A-I      intronic chr9:129634413(+) A-I      intronic chr9:129633745(+) A-I      intronic chr9:129640155(+) A-I      intronic chr9:129640198(+) A-I      intronic chr9:129646380(+) A-I      3'UTR chr9:129633113(+) A-I      intronic chr9:129634140(+) A-I      intronic chr9:129640524(+) A-I      intronic chr9:129640176(+) A-I      intronic chr9:129641128(+) A-I      intronic chr9:129640163(+) A-I      intronic chr9:129641265(+) A-I      intronic chr9:129641103(+) A-I      intronic chr9:129641097(+) A-I      intronic chr9:129641183(+) A-I      intronic chr9:129640642(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB34	chr9:129623014-129623015(+) m6A 5'UTR       24284625 chr9:129641651-129641652(+) m6A 5'UTR//intron       24284625//22608085 chr9:129641694-129641695(+) m6A CDS       24284625//24981863//22575960//22608085 chr9:129641761-129641762(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641779-129641780(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641865-129641866(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642147-129642148(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642291-129642292(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642342-129642343(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642357-129642358(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642484-129642485(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr9:129642732-129642733(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642927-129642928(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642967-129642968(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643038-129643039(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643088-129643089(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643105-129643106(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643111-129643112(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643215-129643216(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643330-129643331(+) m6A 3'UTR       24284625//24981863//22608085 chr9:129643411-129643412(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129643442-129643443(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129644892-129644893(+) m6A 3'UTR       - chr9:129644935-129644936(+) m6A 3'UTR       - chr9:129644970-129644971(+) m6A 3'UTR       - chr9:129646203-129646204(+) m6A 3'UTR       24284625//24981863 chr9:129646209-129646210(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ZBTB34	Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: ZBTB34

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).