Detail Information

Basic Information:


  VIRBase ID:  

HHID00012031

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           CNOT6L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p CNOT6L
miRBase
Accession/Entrez ID		 MIMAT0004593 246175
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CCR4b

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CNOT6L
chr4:78693494(-) A-I      intronic
chr4:78679018(-) A-I      intronic
chr4:78693575(-) A-I      intronic
chr4:78693912(-) A-I      intronic
chr4:78694015(-) A-I      intronic
chr4:78712310(-) A-I      intronic
chr4:78699764(-) A-I      intronic
chr4:78700079(-) A-I      intronic
chr4:78712027(-) A-I      intronic
chr4:78712032(-) A-I      intronic
chr4:78716241(-) A-I      intronic
chr4:78716270(-) A-I      intronic
chr4:78700106(-) A-I      intronic
chr4:78700179(-) A-I      intronic
chr4:78700009(-) A-I      intronic
chr4:78692385(-) A-I      intronic
chr4:78700077(-) A-I      intronic
chr4:78708281(-) A-I      intronic
chr4:78712069(-) A-I      intronic
chr4:78692391(-) A-I      intronic
chr4:78708297(-) A-I      intronic
chr4:78708344(-) A-I      intronic
chr4:78709661(-) A-I      intronic
chr4:78676531(-) A-I      intronic
chr4:78708263(-) A-I      intronic
chr4:78707881(-) A-I      intronic
chr4:78707824(-) A-I      intronic
chr4:78676535(-) A-I      intronic
chr4:78718129(-) A-I      intronic
chr4:78718109(-) A-I      intronic
chr4:78718107(-) A-I      intronic
chr4:78710665(-) A-I      intronic
chr4:78711976(-) A-I      intronic
chr4:78711940(-) A-I      intronic
chr4:78703714(-) A-I      intronic
chr4:78676540(-) A-I      intronic
chr4:78679024(-) A-I      intronic
chr4:78679031(-) A-I      intronic
chr4:78703713(-) A-I      intronic
chr4:78711941(-) A-I      intronic
chr4:78679032(-) A-I      intronic
chr4:78679033(-) A-I      intronic
chr4:78681491(-) A-I      intronic
chr4:78703694(-) A-I      intronic
chr4:78707743(-) A-I      intronic
chr4:78676554(-) A-I      intronic
chr4:78676597(-) A-I      intronic
chr4:78678956(-) A-I      intronic
chr4:78679081(-) A-I      intronic
chr4:78693492(-) A-I      intronic
chr4:78693493(-) A-I      intronic
chr4:78674749(-) A-I      intronic
chr4:78674670(-) A-I      intronic
chr4:78674656(-) A-I      intronic
chr4:78674579(-) A-I      intronic
chr4:78671674(-) A-I      intronic
chr4:78658696(-) A-I      intronic
chr4:78703696(-) A-I      intronic
chr4:78724935(-) A-I      intronic
chr4:78681408(-) A-I      intronic
chr4:78681979(-) A-I      intronic
chr4:78700195(-) A-I      intronic
chr4:78682091(-) A-I      intronic
chr4:78682096(-) A-I      intronic
chr4:78682099(-) A-I      intronic
chr4:78682126(-) A-I      intronic
chr4:78682137(-) A-I      intronic
chr4:78682161(-) A-I      intronic
chr4:78689384(-) A-I      intronic
chr4:78692384(-) A-I      intronic
chr4:78724917(-) A-I      intronic
chr4:78681498(-) A-I      intronic
chr4:78699645(-) A-I      intronic
chr4:78678932(-) A-I      intronic
chr4:78681421(-) A-I      intronic
chr4:78707588(-) A-I      intronic
chr4:78707904(-) A-I      intronic
chr4:78718069(-) A-I      intronic
chr4:78681477(-) A-I      intronic
chr4:78707873(-) A-I      intronic
chr4:78707910(-) A-I      intronic
chr4:78679057(-) A-I      intronic
chr4:78710708(-) A-I      intronic
chr4:78681279(-) A-I      intronic
chr4:78708203(-) A-I      intronic
chr4:78678943(-) A-I      intronic
chr4:78679022(-) A-I      intronic
chr4:78716259(-) A-I      intronic
chr4:78707745(-) A-I      intronic
chr4:78661510(-) A-I      intronic
chr4:78681975(-) A-I      intronic
chr4:78682142(-) A-I      intronic
chr4:78699765(-) A-I      intronic
chr4:78681418(-) A-I      intronic
chr4:78658751(-) A-I      intronic
chr4:78658847(-) A-I      intronic
chr4:78658757(-) A-I      intronic
chr4:78682143(-) A-I      intronic
chr4:78665031(-) A-I      intronic
chr4:78712307(-) A-I      intronic
chr4:78682071(-) A-I      intronic
chr4:78681430(-) A-I      intronic
chr4:78658822(-) A-I      intronic
chr4:78705808(-) A-I      intronic
chr4:78699656(-) A-I      intronic
chr4:78676499(-) A-I      intronic
chr4:78678993(-) A-I      intronic
chr4:78645248(-) A-I      intronic
chr4:78712266(-) A-I      intronic
chr4:78721584(-) A-I      intronic
chr4:78693583(-) A-I      intronic
chr4:78681443(-) A-I      intronic
chr4:78718095(-) A-I      intronic
chr4:78682159(-) A-I      intronic
chr4:78682134(-) A-I      intronic
chr4:78661332(-) A-I      intronic
chr4:78677243(-) A-I      intronic
chr4:78680619(-) A-I      intronic
chr4:78712197(-) A-I      intronic
chr4:78659662(-) A-I      intronic
chr4:78681347(-) A-I      intronic
chr4:78676482(-) A-I      intronic
chr4:78664916(-) A-I      intronic
chr4:78728258(-) A-I      intronic
chr4:78679047(-) A-I      intronic
chr4:78712017(-) A-I      intronic
chr4:78681923(-) A-I      intronic
chr4:78681467(-) A-I      intronic
chr4:78679050(-) A-I      intronic
chr4:78705686(-) A-I      intronic
chr4:78716312(-) A-I      intronic
chr4:78699582(-) A-I      intronic
chr4:78682090(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CNOT6L
chr4:78699645(-) A-G intron -    22484847
chr4:78699765(-) A-G intron -    22484847
chr4:78707523(-) A-G intron -    22484847
chr4:78707577(-) A-G intron -    22484847
chr4:78707588(-) A-G intron -    22484847
chr4:78707873(-) A-G intron -    22484847
chr4:78707910(-) A-G intron -    22484847
chr4:78708203(-) A-G intron -    22484847
chr4:78712197(-) A-G intron -    22484847
chr4:78712307(-) A-G intron -    22484847
chr4:78712428(-) A-G intron -    22484847
chr4:78716298(-) A-G intron -    22484847
chr4:78716410(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CNOT6L
chr4:78641543-78641544(-) m6A 3'UTR       27773535
chr4:78641641-78641642(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr4:78641669-78641670(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr4:78641708-78641709(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr4:78641766-78641767(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
CNOT6L
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: CNOT6L

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...