Basic Information:

  VIRBase ID:  

HHID00012028

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          DOK6:  NM_152721     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	DOK6
miRBase Accession/Entrez ID	MIMAT0004593	220164
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DOK5L//HsT3226

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DOK6	chr18:67072693(+) A-I      intronic chr18:67295606(+) A-I      intronic chr18:67392970(+) A-I      intronic chr18:67447830(+) A-I      intronic chr18:67447831(+) A-I      intronic chr18:67387334(+) A-I      intronic chr18:67251358(+) A-I      intronic chr18:67115884(+) A-I      intronic chr18:67451381(+) A-I      intronic chr18:67085778(+) A-I      intronic chr18:67274064(+) A-I      intronic chr18:67273452(+) A-I      intronic chr18:67412005(+) A-I      intronic chr18:67085988(+) A-I      intronic chr18:67214559(+) A-I      intronic chr18:67408793(+) A-I      intronic chr18:67098032(+) A-I      intronic chr18:67085843(+) A-I      intronic chr18:67295520(+) A-I      intronic chr18:67101882(+) A-I      intronic chr18:67412041(+) A-I      intronic chr18:67470896(+) A-I      intronic chr18:67101905(+) A-I      intronic chr18:67251693(+) A-I      intronic chr18:67273453(+) A-I      intronic chr18:67101904(+) A-I      intronic chr18:67328000(+) A-I      intronic chr18:67392997(+) A-I      intronic chr18:67090508(+) A-I      intronic chr18:67328010(+) A-I      intronic chr18:67409409(+) A-I      intronic chr18:67375814(+) A-I      intronic chr18:67090418(+) A-I      intronic chr18:67412008(+) A-I      intronic chr18:67408820(+) A-I      intronic chr18:67421474(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DOK6	chr18:67327102(+) A-I intron -    15342557 chr18:67327104(+) A-I intron -    15342557 chr18:67327427(+) A-I intron -    15342557 chr18:67327960(+) A-I intron -    15342557 chr18:67328000(+) A-I intron -    15342557 chr18:67328007(+) A-I intron -    15342557 chr18:67328010(+) A-I intron -    15342557 chr18:67328052(+) A-I intron -    15342557 chr18:67408871(+) A-I intron -    22327324 chr18:67404765(+) T-C intron -    22484847 chr18:67458504(+) T-C intron -    22484847 chr18:67488117(+) T-C intron -    22484847 chr18:67488172(+) T-C intron -    22484847 chr18:67491561(+) T-C intron -    22484847 chr18:67499771(+) C-T intron -    22484847 chr18:67408788(+) T-C intron -    22484847 chr18:67408831(+) T-C intron -    22484847 chr18:67408861(+) T-C intron -    22484847 chr18:67408871(+) T-C intron -    22484847 chr18:67408887(+) T-C intron -    22484847 chr18:67408893(+) T-C intron -    22484847 chr18:67408906(+) T-C intron -    22484847 chr18:67408932(+) T-C intron -    22484847 chr18:67413687(+) T-C intron -    22484847 chr18:67421582(+) A-T intron -    22484847 chr18:67502721(+) A-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DOK6	chr18:67508648-67508649(+) m6A 3'UTR       24981863 chr18:67508662-67508663(+) m6A 3'UTR       24981863 chr18:67508700-67508701(+) m6A 3'UTR       24981863 chr18:67508762-67508763(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	DOK6	Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: DOK6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).