Detail Information

Basic Information:


  VIRBase ID:  

HHID00012017

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           PRSS35:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p PRSS35
miRBase
Accession/Entrez ID		 MIMAT0004593 167681
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C6orf158//dJ223E3.1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PRSS35
chr6:84225633(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PRSS35
chr6:84222395-84222396(+) m6A 5'UTR       -
chr6:84222400-84222401(+) m6A 5'UTR       -
chr6:84233205-84233206(+) m6A CDS       22608085
chr6:84233283-84233284(+) m6A CDS       22608085
chr6:84233366-84233367(+) m6A CDS       24981863//22608085
chr6:84233415-84233416(+) m6A CDS       24981863//22608085
chr6:84233439-84233440(+) m6A CDS       24981863//22608085
chr6:84233525-84233526(+) m6A CDS       24981863//22608085
chr6:84233563-84233564(+) m6A CDS       25456834//24981863//22608085
chr6:84233686-84233687(+) m6A CDS       24981863//22608085
chr6:84233913-84233914(+) m6A CDS       25456834//24981863//22608085
chr6:84233980-84233981(+) m6A CDS       25456834//24981863//22608085
chr6:84234035-84234036(+) m6A CDS       24209618//25456834//24981863//22608085
chr6:84234310-84234311(+) m6A CDS       22608085
chr6:84234407-84234408(+) m6A 3'UTR       24981863//22608085
chr6:84234414-84234415(+) m6A 3'UTR       24981863//22608085
chr6:84234447-84234448(+) m6A 3'UTR       24981863//22608085
chr6:84234494-84234495(+) m6A 3'UTR       24981863//22608085
chr6:84234500-84234501(+) m6A 3'UTR       25456834//24981863//22608085
chr6:84234581-84234582(+) m6A 3'UTR       25456834//22608085
chr6:84234675-84234676(+) m6A 3'UTR       22608085
chr6:84234686-84234687(+) m6A 3'UTR       22608085
chr6:84234694-84234695(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PRSS35
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: PRSS35

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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