Detail Information

Basic Information:


  VIRBase ID:  

HHID00012015

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           SPTSSB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p SPTSSB
miRBase
Accession/Entrez ID		 MIMAT0004593 165679
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADMP//C3orf57//SSSPTB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SPTSSB
chr3:161065111(-) A-I      intronic
chr3:161065644(-) A-I      intronic
chr3:161065087(-) A-I      intronic
chr3:161065991(-) A-I      intronic
chr3:161065497(-) A-I      intronic
chr3:161075918(-) A-I      intronic
chr3:161065579(-) A-I      intronic
chr3:161065128(-) A-I      intronic
chr3:161065317(-) A-I      intronic
chr3:161065626(-) A-I      intronic
chr3:161065625(-) A-I      intronic
chr3:161065631(-) A-I      intronic
chr3:161065100(-) A-I      intronic
chr3:161065339(-) A-I      intronic
chr3:161074764(-) A-I      intronic
chr3:161065661(-) A-I      intronic
chr3:161065456(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPTSSB
chr3:161077598-161077599(-) m6A 5'UTR//exon       27773535
chr3:161077604-161077605(-) m6A 5'UTR//exon       27773535
chr3:161077609-161077610(-) m6A 5'UTR//exon       27773535
chr3:161077653-161077654(-) m6A 5'UTR//exon       27773535
chr3:161077673-161077674(-) m6A 5'UTR//exon       27773535
chr3:161089338-161089339(-) m6A 3'UTR//5'UTR       27773535
chr3:161089440-161089441(-) m6A 3'UTR//5'UTR       25456834//27773535
chr3:161089519-161089520(-) m6A 3'UTR//5'UTR       25456834//24981863//28052920//27773535
chr3:161089549-161089550(-) m6A 3'UTR//5'UTR       25456834//24981863//28052920//27773535
chr3:161089568-161089569(-) m6A 3'UTR//5'UTR       25456834//24981863//28052920//27773535
chr3:161089614-161089615(-) m6A 3'UTR//5'UTR       25456834//28052920//27773535
chr3:161089635-161089636(-) m6A 3'UTR//5'UTR       25456834//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SPTSSB
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: SPTSSB

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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