Basic Information:

  VIRBase ID:  

HHID00011983

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          RALYL:  NM_001354318     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	RALYL
miRBase Accession/Entrez ID	MIMAT0004593	138046
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HNRPCL3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RALYL	chr8:85104848(+) A-I      intronic chr8:85166952(+) A-I      intronic chr8:85104854(+) A-I      intronic chr8:85104892(+) A-I      intronic chr8:85104920(+) A-I      intronic chr8:85104922(+) A-I      intronic chr8:85104954(+) A-I      intronic chr8:85166942(+) A-I      intronic chr8:85166950(+) A-I      intronic chr8:85151935(+) A-I      intronic chr8:85114746(+) A-I      intronic chr8:85166960(+) A-I      intronic chr8:85114712(+) A-I      intronic chr8:85166954(+) A-I      intronic chr8:85104910(+) A-I      intronic chr8:85166953(+) A-I      intronic chr8:85591857(+) A-I      intronic chr8:85804738(+) A-I      intronic chr8:85591873(+) A-I      intronic chr8:85591864(+) A-I      intronic chr8:85591859(+) A-I      intronic chr8:85166956(+) A-I      intronic chr8:85391174(+) A-I      intronic chr8:85279402(+) A-I      intronic chr8:85222147(+) A-I      intronic chr8:85147180(+) A-I      intronic chr8:85278899(+) A-I      intronic chr8:85278854(+) A-I      intronic chr8:85223028(+) A-I      intronic chr8:85218252(+) A-I      intronic chr8:85218284(+) A-I      intronic chr8:85104932(+) A-I      intronic chr8:85387478(+) A-I      intronic chr8:85278857(+) A-I      intronic chr8:85488120(+) A-I      intronic chr8:85467349(+) A-I      intronic chr8:85387499(+) A-I      intronic chr8:85498182(+) A-I      intronic chr8:85104926(+) A-I      intronic chr8:85279693(+) A-I      intronic chr8:85449602(+) A-I      intronic chr8:85701972(+) A-I      intronic chr8:85109993(+) A-I      intronic chr8:85416079(+) A-I      intronic chr8:85226900(+) A-I      intronic chr8:85312354(+) A-I      intronic chr8:85279470(+) A-I      intronic chr8:85107513(+) A-I      intronic chr8:85223036(+) A-I      intronic chr8:85151965(+) A-I      intronic chr8:85387585(+) A-I      intronic chr8:85278863(+) A-I      intronic chr8:85153835(+) A-I      intronic chr8:85383682(+) A-I      intronic chr8:85279488(+) A-I      intronic chr8:85426261(+) A-I      intronic chr8:85104897(+) A-I      intronic chr8:85226887(+) A-I      intronic chr8:85104927(+) A-I      intronic chr8:85279687(+) A-I      intronic chr8:85278800(+) A-I      intronic chr8:85415470(+) A-I      intronic chr8:85113927(+) A-I      intronic chr8:85223027(+) A-I      intronic chr8:85426286(+) A-I      intronic chr8:85110011(+) A-I      intronic chr8:85278859(+) A-I      intronic chr8:85226854(+) A-I      intronic chr8:85278754(+) A-I      intronic chr8:85438464(+) A-I      intronic chr8:85728149(+) A-I      intronic chr8:85458414(+) A-I      intronic chr8:85153840(+) A-I      intronic chr8:85415452(+) A-I      intronic chr8:85222526(+) A-I      intronic chr8:85147043(+) A-I      intronic chr8:85397762(+) A-I      intronic chr8:85279471(+) A-I      intronic chr8:85222417(+) A-I      intronic chr8:85279414(+) A-I      intronic chr8:85151979(+) A-I      intronic chr8:85153906(+) A-I      intronic chr8:85107625(+) A-I      intronic chr8:85216559(+) A-I      intronic chr8:85258830(+) A-I      intronic chr8:85279686(+) A-I      intronic chr8:85125479(+) A-I      intronic chr8:85278762(+) A-I      intronic chr8:85104836(+) A-I      intronic chr8:85151983(+) A-I      intronic chr8:85151970(+) A-I      intronic chr8:85426210(+) A-I      intronic chr8:85278826(+) A-I      intronic chr8:85278824(+) A-I      intronic chr8:85222169(+) A-I      intronic chr8:85216378(+) A-I      intronic chr8:85278931(+) A-I      intronic chr8:85279518(+) A-I      intronic chr8:85686196(+) A-I      intronic chr8:85590723(+) A-I      intronic chr8:85467354(+) A-I      intronic chr8:85415422(+) A-I      intronic chr8:85222536(+) A-I      intronic chr8:85501189(+) A-I      intronic chr8:85258887(+) A-I      intronic chr8:85104841(+) A-I      intronic chr8:85312196(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RALYL	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: RALYL

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).