Basic Information:

  VIRBase ID:  

HHID00011976

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          TMEM170A:  NM_145254     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	TMEM170A
miRBase Accession/Entrez ID	MIMAT0004593	124491
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM170

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM170A	chr16:75482768(-) A-I      intronic chr16:75482915(-) A-I      intronic chr16:75484733(-) A-I      intronic chr16:75483435(-) A-I      intronic chr16:75482847(-) A-I      intronic chr16:75482787(-) A-I      intronic chr16:75482742(-) A-I      intronic chr16:75482909(-) A-I      intronic chr16:75483436(-) A-I      intronic chr16:75492854(-) A-I      intronic chr16:75483489(-) A-I      intronic chr16:75483421(-) A-I      intronic chr16:75483288(-) A-I      intronic chr16:75482897(-) A-I      intronic chr16:75482851(-) A-I      intronic chr16:75482743(-) A-I      intronic chr16:75493083(-) A-I      intronic chr16:75482416(-) A-I      intronic chr16:75492974(-) A-I      intronic chr16:75489171(-) A-I      intronic chr16:75486446(-) A-I      intronic chr16:75487237(-) A-I      intronic chr16:75489168(-) A-I      intronic chr16:75487318(-) A-I      intronic chr16:75487291(-) A-I      intronic chr16:75493655(-) A-I      intronic chr16:75493679(-) A-I      intronic chr16:75493753(-) A-I      intronic chr16:75496256(-) A-I      intronic chr16:75496353(-) A-I      intronic chr16:75484740(-) A-I      intronic chr16:75484810(-) A-I      intronic chr16:75485231(-) A-I      intronic chr16:75487275(-) A-I      intronic chr16:75487288(-) A-I      intronic chr16:75487147(-) A-I      intronic chr16:75484670(-) A-I      intronic chr16:75493059(-) A-I      intronic chr16:75493065(-) A-I      intronic chr16:75485230(-) A-I      intronic chr16:75487115(-) A-I      intronic chr16:75489575(-) A-I      intronic chr16:75493510(-) A-I      intronic chr16:75484726(-) A-I      intronic chr16:75483416(-) A-I      intronic chr16:75487160(-) A-I      intronic chr16:75492888(-) A-I      intronic chr16:75482902(-) A-I      intronic chr16:75485299(-) A-I      intronic chr16:75486526(-) A-I      intronic chr16:75482794(-) A-I      intronic chr16:75483294(-) A-I      intronic chr16:75493716(-) A-I      intronic chr16:75490275(-) A-I      intronic chr16:75482921(-) A-I      intronic chr16:75482816(-) A-I      intronic chr16:75496255(-) A-I      intronic chr16:75487129(-) A-I      intronic chr16:75484763(-) A-I      intronic chr16:75485298(-) A-I      intronic chr16:75484742(-) A-I      intronic chr16:75485272(-) A-I      intronic chr16:75496272(-) A-I      intronic chr16:75482772(-) A-I      intronic chr16:75482756(-) A-I      intronic chr16:75485338(-) A-I      intronic chr16:75485278(-) A-I      intronic chr16:75486481(-) A-I      intronic chr16:75493589(-) A-I      intronic chr16:75496278(-) A-I      intronic chr16:75486597(-) A-I      intronic chr16:75487216(-) A-I      intronic chr16:75489521(-) A-I      intronic chr16:75486141(-) A-I      intronic chr16:75493575(-) A-I      intronic chr16:75488999(-) A-I      intronic chr16:75486459(-) A-I      intronic chr16:75496284(-) A-I      intronic chr16:75484721(-) A-I      intronic chr16:75490251(-) A-I      intronic chr16:75493673(-) A-I      intronic chr16:75483268(-) A-I      intronic chr16:75483449(-) A-I      intronic chr16:75483318(-) A-I      intronic chr16:75482716(-) A-I      intronic chr16:75490274(-) A-I      intronic chr16:75496303(-) A-I      intronic chr16:75485364(-) A-I      intronic chr16:75484855(-) A-I      intronic chr16:75489591(-) A-I      intronic chr16:75496310(-) A-I      intronic chr16:75483420(-) A-I      intronic chr16:75482907(-) A-I      intronic chr16:75486304(-) A-I      intronic chr16:75482882(-) A-I      intronic chr16:75487139(-) A-I      intronic chr16:75485191(-) A-I      intronic chr16:75482714(-) A-I      intronic chr16:75490330(-) A-I      intronic chr16:75490369(-) A-I      intronic chr16:75484588(-) A-I      intronic chr16:75493633(-) A-I      intronic chr16:75486259(-) A-I      intronic chr16:75483443(-) A-I      intronic chr16:75482913(-) A-I      intronic chr16:75484755(-) A-I      intronic chr16:75485325(-) A-I      intronic chr16:75496224(-) A-I      intronic chr16:75483373(-) A-I      intronic chr16:75482793(-) A-I      intronic chr16:75484793(-) A-I      intronic chr16:75483512(-) A-I      intronic chr16:75482540(-) A-I      intronic chr16:75487166(-) A-I      intronic chr16:75484833(-) A-I      intronic chr16:75489088(-) A-I      intronic chr16:75485202(-) A-I      intronic chr16:75484729(-) A-I      intronic chr16:75485203(-) A-I      intronic chr16:75486460(-) A-I      intronic chr16:75484759(-) A-I      intronic chr16:75482843(-) A-I      intronic chr16:75487220(-) A-I      intronic chr16:75493081(-) A-I      intronic chr16:75489581(-) A-I      intronic chr16:75484600(-) A-I      intronic chr16:75487135(-) A-I      intronic chr16:75489091(-) A-I      intronic chr16:75483450(-) A-I      intronic chr16:75484739(-) A-I      intronic chr16:75489565(-) A-I      intronic chr16:75484832(-) A-I      intronic chr16:75483434(-) A-I      intronic chr16:75496223(-) A-I      intronic chr16:75483351(-) A-I      intronic chr16:75487114(-) A-I      intronic chr16:75486594(-) A-I      intronic chr16:75484792(-) A-I      intronic chr16:75489529(-) A-I      intronic chr16:75484734(-) A-I      intronic chr16:75482703(-) A-I      intronic chr16:75482495(-) A-I      intronic chr16:75485323(-) A-I      intronic chr16:75490230(-) A-I      intronic chr16:75492920(-) A-I      intronic chr16:75486588(-) A-I      intronic chr16:75482715(-) A-I      intronic chr16:75489066(-) A-I      intronic chr16:75483490(-) A-I      intronic chr16:75492897(-) A-I      intronic chr16:75482835(-) A-I      intronic chr16:75482837(-) A-I      intronic chr16:75483328(-) A-I      intronic chr16:75483472(-) A-I      intronic chr16:75482850(-) A-I      intronic chr16:75484783(-) A-I      intronic chr16:75482757(-) A-I      intronic chr16:75487232(-) A-I      intronic chr16:75482498(-) A-I      intronic chr16:75493708(-) A-I      intronic chr16:75485431(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM170A	chr16:75482843(-) A-I intron -    22327324 chr16:75482757(-) A-G intron -    22484847 chr16:75482793(-) A-G intron -    22484847 chr16:75482816(-) A-G intron -    22484847 chr16:75482843(-) A-G intron -    22484847 chr16:75482913(-) A-G intron -    22484847 chr16:75482921(-) A-G intron -    22484847 chr16:75483294(-) A-G intron -    22484847 chr16:75484739(-) A-G intron -    22484847 chr16:75484759(-) A-G intron -    22484847 chr16:75484793(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM170A	chr16:75479159-75479160(-) m6A 3'UTR       - chr16:75479186-75479187(-) m6A 3'UTR       - chr16:75479234-75479235(-) m6A 3'UTR       27773535 chr16:75479259-75479260(-) m6A 3'UTR       - chr16:75479272-75479273(-) m6A 3'UTR       - chr16:75479502-75479503(-) m6A 3'UTR//intron       24981863 chr16:75479524-75479525(-) m6A 3'UTR//intron       24981863 chr16:75479529-75479530(-) m6A 3'UTR//intron       24981863 chr16:75481248-75481249(-) m6A 3'UTR       25456834//24981863//27773535//22608085 chr16:75481270-75481271(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr16:75481280-75481281(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr16:75481328-75481329(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr16:75481337-75481338(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr16:75481343-75481344(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr16:75481422-75481423(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr16:75481428-75481429(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr16:75481509-75481510(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//22608085 chr16:75485556-75485557(-) m6A CDS//intron       22608085 chr16:75485591-75485592(-) m6A CDS//intron       24209618//22608085 chr16:75485648-75485649(-) m6A CDS       24209618//24981863//27773535//22608085 chr16:75486553-75486554(-) m6A 5'UTR//intron       24209618 chr16:75498404-75498405(-) m6A CDS//intron       27773535 chr16:75498601-75498602(-) m6A 5'UTR//intron       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TMEM170A	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: TMEM170A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).