Detail Information

Basic Information:


  VIRBase ID:  

HHID00011969

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           MED12L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p MED12L
miRBase
Accession/Entrez ID		 MIMAT0004593 116931
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NIZIDS//NOPAR//TNRC11L//TRALP//TRALPUSH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MED12L
chr3:151144718(+) A-I      intronic
chr3:151144680(+) A-I      intronic
chr3:151144705(+) A-I      intronic
chr3:151144706(+) A-I      intronic
chr3:150911898(+) A-I      intronic
chr3:150911918(+) A-I      intronic
chr3:150911943(+) A-I      intronic
chr3:150911951(+) A-I      intronic
chr3:150911919(+) A-I      intronic
chr3:150911954(+) A-I      intronic
chr3:150899286(+) A-I      intronic
chr3:151123326(+) A-I      intronic
chr3:151127475(+) A-I      intronic
chr3:151127492(+) A-I      intronic
chr3:150926420(+) A-I      intronic
chr3:151022323(+) A-I      intronic
chr3:151022308(+) A-I      intronic
chr3:151124691(+) A-I      intronic
chr3:150912797(+) A-I      intronic
chr3:150833343(+) A-I      intronic
chr3:150896943(+) A-I      intronic
chr3:151127679(+) A-I      intronic
chr3:150912697(+) A-I      intronic
chr3:151002536(+) A-I      intronic
chr3:151131683(+) A-I      intronic
chr3:150895394(+) A-I      intronic
chr3:151123318(+) A-I      intronic
chr3:151003018(+) A-I      intronic
chr3:150909572(+) A-I      intronic
chr3:151131684(+) A-I      intronic
chr3:150813646(+) A-I      intronic
chr3:150833590(+) A-I      intronic
chr3:151142138(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MED12L
chr3:150803558-150803559(+) m6A exon       -
chr3:150803568-150803569(+) m6A exon       -
chr3:150905952-150905953(+) m5C intron       23604283
chr3:151131003-151131004(+) m6A CDS//intron       -
chr3:151131046-151131047(+) m6A CDS//intron       -
chr3:151131073-151131074(+) m6A CDS//intron       -
chr3:151150993-151150994(+) m6A 3'UTR       22608085
chr3:151151003-151151004(+) m6A 3'UTR       22608085
chr3:151151008-151151009(+) m6A 3'UTR       22608085
chr3:151151045-151151046(+) m6A 3'UTR       22608085
chr3:151151088-151151089(+) m6A 3'UTR       22608085
chr3:151154215-151154216(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MED12L
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: MED12L

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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