Basic Information:

  VIRBase ID:  

HHID00011968

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          RAB39B:  NM_171998     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	RAB39B
miRBase Accession/Entrez ID	MIMAT0004593	116442
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BGMR//MRX72//WSMN//WSN

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB39B	chrX:154488042-154488043(-) Y 3'UTR       26075521 chrX:154489756-154489757(-) m6A 3'UTR       - chrX:154489761-154489762(-) m6A 3'UTR       - chrX:154489773-154489774(-) m6A 3'UTR       25456834 chrX:154489819-154489820(-) m6A 3'UTR       25456834//22608085 chrX:154489900-154489901(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154489946-154489947(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154489956-154489957(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154490001-154490002(-) m6A 3'UTR       25456834//24981863//27773535//27371828//22608085 chrX:154490048-154490049(-) m6A 3'UTR       25456834//27773535//22608085 chrX:154490066-154490067(-) m6A 3'UTR       25456834//27773535//22608085 chrX:154490220-154490221(-) m6A CDS       24981863//27773535//22608085 chrX:154490232-154490233(-) m6A CDS       24981863//27773535//22608085 chrX:154490309-154490310(-) m6A CDS       24981863//27773535//22608085 chrX:154490410-154490411(-) m6A CDS       24981863//27773535//22608085 chrX:154490487-154490488(-) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RAB39B	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: RAB39B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).