Basic Information:

  VIRBase ID:  

HHID00011967

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          FBXO32:  NM_058229     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	FBXO32
miRBase Accession/Entrez ID	MIMAT0004593	114907
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Fbx32//MAFbx

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FBXO32	chr8:124528185(-) A-I      intronic chr8:124527614(-) A-I      intronic chr8:124528201(-) A-I      intronic chr8:124532156(-) A-I      intronic chr8:124534510(-) A-I      intronic chr8:124534517(-) A-I      intronic chr8:124534534(-) A-I      intronic chr8:124528188(-) A-I      intronic chr8:124521692(-) A-I      intronic chr8:124532188(-) A-I      intronic chr8:124532197(-) A-I      intronic chr8:124534560(-) A-I      intronic chr8:124532201(-) A-I      intronic chr8:124532207(-) A-I      intronic chr8:124521689(-) A-I      intronic chr8:124521697(-) A-I      intronic chr8:124521723(-) A-I      intronic chr8:124532223(-) A-I      intronic chr8:124534551(-) A-I      intronic chr8:124534554(-) A-I      intronic chr8:124521683(-) A-I      intronic chr8:124534573(-) A-I      intronic chr8:124534577(-) A-I      intronic chr8:124534570(-) A-I      intronic chr8:124528146(-) A-I      intronic chr8:124535638(-) A-I      intronic chr8:124535618(-) A-I      intronic chr8:124521735(-) A-I      intronic chr8:124535667(-) A-I      intronic chr8:124535706(-) A-I      intronic chr8:124535708(-) A-I      intronic chr8:124535658(-) A-I      intronic chr8:124527565(-) A-I      intronic chr8:124532166(-) A-I      intronic chr8:124527549(-) A-I      intronic chr8:124524011(-) A-I      intronic chr8:124521783(-) A-I      intronic chr8:124523904(-) A-I      intronic chr8:124523844(-) A-I      intronic chr8:124527659(-) A-I      intronic chr8:124527660(-) A-I      intronic chr8:124523789(-) A-I      intronic chr8:124523784(-) A-I      intronic chr8:124523743(-) A-I      intronic chr8:124522847(-) A-I      intronic chr8:124522771(-) A-I      intronic chr8:124521796(-) A-I      intronic chr8:124521760(-) A-I      intronic chr8:124521736(-) A-I      intronic chr8:124521722(-) A-I      intronic chr8:124521719(-) A-I      intronic chr8:124521705(-) A-I      intronic chr8:124527682(-) A-I      intronic chr8:124521774(-) A-I      intronic chr8:124527684(-) A-I      intronic chr8:124527716(-) A-I      intronic chr8:124527578(-) A-I      intronic chr8:124531233(-) A-I      intronic chr8:124527581(-) A-I      intronic chr8:124527600(-) A-I      intronic chr8:124528008(-) A-I      intronic chr8:124528020(-) A-I      intronic chr8:124531739(-) A-I      intronic chr8:124531138(-) A-I      intronic chr8:124531146(-) A-I      intronic chr8:124532090(-) A-I      intronic chr8:124532117(-) A-I      intronic chr8:124532160(-) A-I      intronic chr8:124532165(-) A-I      intronic chr8:124528169(-) A-I      intronic chr8:124523827(-) A-I      intronic chr8:124528175(-) A-I      intronic chr8:124531169(-) A-I      intronic chr8:124528120(-) A-I      intronic chr8:124531314(-) A-I      intronic chr8:124531265(-) A-I      intronic chr8:124534597(-) A-I      intronic chr8:124527721(-) A-I      intronic chr8:124527513(-) A-I      intronic chr8:124532309(-) A-I      intronic chr8:124531313(-) A-I      intronic chr8:124534587(-) A-I      intronic chr8:124531604(-) A-I      intronic chr8:124527977(-) A-I      intronic chr8:124527630(-) A-I      intronic chr8:124528040(-) A-I      intronic chr8:124522784(-) A-I      intronic chr8:124534540(-) A-I      intronic chr8:124535645(-) A-I      intronic chr8:124522758(-) A-I      intronic chr8:124531140(-) A-I      intronic chr8:124523884(-) A-I      intronic chr8:124531165(-) A-I      intronic chr8:124532222(-) A-I      intronic chr8:124535825(-) A-I      intronic chr8:124521845(-) A-I      intronic chr8:124521935(-) A-I      intronic chr8:124522846(-) A-I      intronic chr8:124521777(-) A-I      intronic chr8:124528231(-) A-I      intronic chr8:124534539(-) A-I      intronic chr8:124532270(-) A-I      intronic chr8:124531789(-) A-I      intronic chr8:124523895(-) A-I      intronic chr8:124534521(-) A-I      intronic chr8:124532094(-) A-I      intronic chr8:124531537(-) A-I      intronic chr8:124532082(-) A-I      intronic chr8:124521748(-) A-I      intronic chr8:124535815(-) A-I      intronic chr8:124523854(-) A-I      intronic chr8:124531354(-) A-I      intronic chr8:124523898(-) A-I      intronic chr8:124534722(-) A-I      intronic chr8:124534622(-) A-I      intronic chr8:124542947(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FBXO32	chr8:124531265(-) A-I intron -    21960545 chr8:124534622(-) A-I intron -    21960545 chr8:124535589(-) A-I intron -    21960545 chr8:124531604(-) A-G intron -    22484847 chr8:124532222(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FBXO32	chr8:124513248-124513249(-) m6A 3'UTR       - chr8:124513265-124513266(-) m6A 3'UTR       - chr8:124513271-124513272(-) m6A 3'UTR       - chr8:124513285-124513286(-) m6A 3'UTR       - chr8:124514486-124514487(-) m6A 3'UTR       - chr8:124514511-124514512(-) m6A 3'UTR       22608085 chr8:124514544-124514545(-) m6A 3'UTR       22608085 chr8:124514588-124514589(-) m6A 3'UTR       22608085 chr8:124514607-124514608(-) m6A 3'UTR       22608085 chr8:124515182-124515183(-) m6A 3'UTR       - chr8:124515255-124515256(-) m6A 3'UTR       24209618//22608085 chr8:124515290-124515291(-) m6A 3'UTR       24209618//24981863//22608085 chr8:124515351-124515352(-) m6A 3'UTR//exon       24209618//24981863//22608085 chr8:124515379-124515380(-) m6A 3'UTR//exon       24209618//24981863//22608085 chr8:124515424-124515425(-) m6A 3'UTR//exon       24209618//24981863//22608085 chr8:124515473-124515474(-) m6A 3'UTR//exon       24209618//24981863//22608085 chr8:124515498-124515499(-) m6A 3'UTR//exon       24209618//24981863//22608085 chr8:124515511-124515512(-) m6A 3'UTR//exon       24209618//24981863//22608085 chr8:124515542-124515543(-) m6A 3'UTR//exon       24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	FBXO32	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: FBXO32

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).