Detail Information

Basic Information:


  VIRBase ID:  

HHID00011956

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           IGSF8:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p IGSF8
miRBase
Accession/Entrez ID		 MIMAT0004593 93185
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD316//CD81P3//EWI-2//EWI2//KCT-4//LIR-D1//PGRL

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IGSF8
chr1:160066339(-) A-I      intronic
chr1:160065619(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IGSF8
chr1:160061147-160061148(-) m6A 3'UTR       27773535
chr1:160061339-160061340(-) m6A 3'UTR       24284625//27773535
chr1:160062207-160062208(-) m6A CDS       27371828//27773536
chr1:160062381-160062382(-) m6A CDS       25456834//27371828//27773536
chr1:160062428-160062429(-) m6A CDS       27371828
chr1:160062863-160062864(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr1:160062937-160062938(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr1:160062997-160062998(-) Tm CDS       -
chr1:160062997-160062998(-) Y CDS       26075521
chr1:160063056-160063057(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr1:160063655-160063656(-) m6A CDS//exon       24284625//27773535//27371828//27773536
chr1:160063729-160063730(-) m6A CDS//exon       24284625//27773535//27371828//27773536
chr1:160063835-160063836(-) m6A CDS//exon       24284625//27371828//27773536
chr1:160068305-160068306(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536
chr1:160068455-160068456(-) m6A 5'UTR//intron       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
IGSF8
Chromatin K562 cells     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: IGSF8

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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