Detail Information

Basic Information:


  VIRBase ID:  

HHID00011955

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           SPSB4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p SPSB4
miRBase
Accession/Entrez ID		 MIMAT0004593 92369
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SSB-4//SSB4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPSB4
chr3:140785058-140785059(+) m6A CDS       25456834
chr3:140785070-140785071(+) m6A CDS       25456834
chr3:140785115-140785116(+) m6A CDS       25456834
chr3:140785124-140785125(+) m6A CDS       25456834
chr3:140785373-140785374(+) m6A CDS       25456834
chr3:140785409-140785410(+) m6A CDS       25456834
chr3:140785490-140785491(+) m6A CDS       25456834
chr3:140851145-140851146(+) m6A 3'UTR//intron       -
chr3:140866004-140866005(+) m6A 3'UTR//CDS//exon       25456834
chr3:140866055-140866056(+) m6A 3'UTR//CDS//exon       25456834//24981863//22608085
chr3:140866091-140866092(+) m6A 3'UTR//CDS//exon       25456834//24981863//22608085
chr3:140866134-140866135(+) m6A 3'UTR//exon       25456834//24981863//22608085
chr3:140866140-140866141(+) m6A 3'UTR//exon       25456834//24981863//22608085
chr3:140866227-140866228(+) m6A 3'UTR//exon       25456834//22608085
chr3:140866246-140866247(+) m6A 3'UTR//exon       24209618//25456834//22608085
chr3:140866329-140866330(+) m6A 3'UTR       22608085
chr3:140866395-140866396(+) m6A 3'UTR       24981863//22608085
chr3:140866454-140866455(+) m6A 3'UTR       24981863//22608085
chr3:140866469-140866470(+) m6A 3'UTR       24981863//22608085
chr3:140866495-140866496(+) m6A 3'UTR       24981863//22608085
chr3:140866627-140866628(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140866647-140866648(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140866673-140866674(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140866686-140866687(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140866702-140866703(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140866797-140866798(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140866905-140866906(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140866937-140866938(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr3:140867084-140867085(+) m6A 3'UTR       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SPSB4
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: SPSB4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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