Basic Information:

  VIRBase ID:  

HHID00011953

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          TMEM263:  NM_001319662     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	TMEM263
miRBase Accession/Entrez ID	MIMAT0004593	90488
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C12orf23

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM263	chr12:107354936(+) A-I      intronic chr12:107361239(+) A-I      intronic chr12:107359300(+) A-I      intronic chr12:107361137(+) A-I      intronic chr12:107354975(+) A-I      intronic chr12:107361166(+) A-I      intronic chr12:107361176(+) A-I      intronic chr12:107359264(+) A-I      intronic chr12:107359270(+) A-I      intronic chr12:107354889(+) A-I      intronic chr12:107359238(+) A-I      intronic chr12:107355106(+) A-I      intronic chr12:107359156(+) A-I      intronic chr12:107353204(+) A-I      intronic chr12:107359294(+) A-I      intronic chr12:107359306(+) A-I      intronic chr12:107359130(+) A-I      intronic chr12:107363250(+) A-I      intronic chr12:107359329(+) A-I      intronic chr12:107361067(+) A-I      intronic chr12:107359242(+) A-I      intronic chr12:107354935(+) A-I      intronic chr12:107359129(+) A-I      intronic chr12:107359288(+) A-I      intronic chr12:107354939(+) A-I      intronic chr12:107359184(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM263	chr12:107350867-107350868(+) m6A 5'UTR//intron       24209618 chr12:107360903-107360904(+) m6A CDS       24284625//22608085 chr12:107360947-107360948(+) m6A CDS       24284625//24981863//22608085 chr12:107365025-107365026(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:107365125-107365126(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:107365155-107365156(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:107365235-107365236(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr12:107365275-107365276(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:107365324-107365325(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr12:107366729-107366730(+) m6A 3'UTR//intron       24981863 chr12:107367499-107367500(+) m6A 3'UTR//intron       27773535 chr12:107367504-107367505(+) m6A 3'UTR//intron       27773535 chr12:107367522-107367523(+) m6A 3'UTR//intron       27773535 chr12:107367601-107367602(+) m6A 3'UTR//intron       27773535 chr12:107367724-107367725(+) m6A 3'UTR//intron       27773535 chr12:107367801-107367802(+) m6A 3'UTR//intron       27773535 chr12:107367809-107367810(+) m6A 3'UTR//intron       27773535 chr12:107369983-107369984(+) m6A exon//intron       24284625//22608085 chr12:107369987-107369988(+) m6A exon//intron       24284625//24981863//27773535 chr12:107372168-107372169(+) m6A exon       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085 chr12:107372175-107372176(+) m6A exon       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085 chr12:107372327-107372328(+) m6A exon       24284625//24209618//24981863//27773535//22575960//22608085 chr12:107372447-107372448(+) m6A exon       24284625//24209618//24981863//27773535//22608085 chr12:107372461-107372462(+) m6A exon       24284625//24209618//24981863//27773535//22608085 chr12:107372528-107372529(+) m6A exon       24284625//24209618//24981863//27773535//22608085 chr12:107372538-107372539(+) m6A exon       24284625//24209618//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TMEM263	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: TMEM263

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).