Basic Information:

  VIRBase ID:  

HHID00011916

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          MYCT1:  NM_025107     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	MYCT1
miRBase Accession/Entrez ID	MIMAT0004593	80177
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MTLC

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MYCT1	chr6:153026380(+) A-I      intronic chr6:153027821(+) A-I      intronic chr6:153027771(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MYCT1	chr6:153043046-153043047(+) m6A CDS//intron       24981863 chr6:153043132-153043133(+) m6A CDS//intron       24981863 chr6:153043217-153043218(+) m6A CDS//intron       - chr6:153043459-153043460(+) m6A 3'UTR//intron       - chr6:153043508-153043509(+) m6A 3'UTR//intron       - chr6:153043527-153043528(+) m6A 3'UTR//intron       - chr6:153043542-153043543(+) m6A 3'UTR//intron       - chr6:153043557-153043558(+) m6A 3'UTR//intron       - chr6:153043893-153043894(+) m6A 3'UTR//intron       - chr6:153043943-153043944(+) m6A 3'UTR       24209618//24981863 chr6:153044009-153044010(+) m6A 3'UTR       24209618//24981863 chr6:153044098-153044099(+) m6A 3'UTR       24209618//24981863 chr6:153044106-153044107(+) m6A 3'UTR       24209618//24981863 chr6:153044202-153044203(+) m6A 3'UTR       24209618//24981863 chr6:153044209-153044210(+) m6A 3'UTR       24209618//24981863 chr6:153044252-153044253(+) m6A 3'UTR       24209618//24981863 chr6:153044267-153044268(+) m6A 3'UTR       24209618//24981863 chr6:153044272-153044273(+) m6A 3'UTR       24209618//24981863 chr6:153044322-153044323(+) m6A 3'UTR       24209618//24981863 chr6:153044476-153044477(+) m6A 3'UTR       - chr6:153044494-153044495(+) m6A 3'UTR       - chr6:153044537-153044538(+) m6A 3'UTR       - chr6:153044597-153044598(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	MYCT1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: MYCT1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).