Detail Information

Basic Information:


  VIRBase ID:  

HHID00011912

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           SEMA6D:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p SEMA6D
miRBase
Accession/Entrez ID		 MIMAT0004593 80031
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SEMA6D
chr15:47772290(+) A-I      intronic
chr15:47979062(+) A-I      intronic
chr15:48045134(+) A-I      intronic
chr15:47632055(+) A-I      intronic
chr15:47631981(+) A-I      intronic
chr15:47979061(+) A-I      intronic
chr15:47586560(+) A-I      intronic
chr15:48027546(+) A-I      intronic
chr15:47885422(+) A-I      intronic
chr15:47885421(+) A-I      intronic
chr15:48022758(+) A-I      intronic
chr15:47657938(+) A-I      intronic
chr15:47885385(+) A-I      intronic
chr15:47979081(+) A-I      intronic
chr15:47598740(+) A-I      intronic
chr15:48022790(+) A-I      intronic
chr15:47979156(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SEMA6D
chr15:48022758(+) A-I intron -    22327324
chr15:48022776(+) A-I intron -    22327324
chr15:48022790(+) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SEMA6D
chr15:47476376-47476377(+) m6A 5'UTR       -
chr15:47476398-47476399(+) m6A 5'UTR       -
chr15:47476408-47476409(+) m6A 5'UTR       -
chr15:48010739-48010740(+) m6A 5'UTR//intron       -
chr15:48062822-48062823(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48062840-48062841(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48062885-48062886(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48062907-48062908(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48062967-48062968(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063038-48063039(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063109-48063110(+) m6A 3'UTR//CDS       24284625
chr15:48063172-48063173(+) m6A 3'UTR//CDS       24284625
chr15:48063287-48063288(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063323-48063324(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063455-48063456(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063476-48063477(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063639-48063640(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr15:48063698-48063699(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr15:48063704-48063705(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr15:48063732-48063733(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr15:48063746-48063747(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr15:48063788-48063789(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063802-48063803(+) m6A 3'UTR//CDS       24284625//22608085
chr15:48063840-48063841(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085
chr15:48063882-48063883(+) m6A 3'UTR//CDS       24284625//25456834//22608085
chr15:48063906-48063907(+) m6A 3'UTR//CDS       24284625//25456834//22608085
chr15:48063943-48063944(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085
chr15:48063957-48063958(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085
chr15:48063965-48063966(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr15:48064059-48064060(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr15:48064066-48064067(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr15:48064087-48064088(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr15:48064104-48064105(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr15:48064131-48064132(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr15:48064181-48064182(+) m6A 3'UTR       24284625//22608085
chr15:48064298-48064299(+) m6A 3'UTR       24284625//22608085
chr15:48064327-48064328(+) m6A 3'UTR       24284625//22608085
chr15:48064362-48064363(+) m6A 3'UTR       24284625//22608085
chr15:48064439-48064440(+) m6A 3'UTR       24284625//22608085
chr15:48064673-48064674(+) m6A 3'UTR       24284625
chr15:48064758-48064759(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SEMA6D
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: SEMA6D

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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