Detail Information

Basic Information:


  VIRBase ID:  

HHID00011911

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           BORA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p BORA
miRBase
Accession/Entrez ID		 MIMAT0004593 79866
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C13orf34

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BORA
chr13:73305018(+) A-I      intronic
chr13:73306557(+) A-I      intronic
chr13:73306631(+) A-I      intronic
chr13:73309865(+) A-I      intronic
chr13:73309812(+) A-I      intronic
chr13:73304974(+) A-I      intronic
chr13:73306775(+) A-I      intronic
chr13:73309957(+) A-I      intronic
chr13:73306551(+) A-I      intronic
chr13:73304979(+) A-I      intronic
chr13:73306558(+) A-I      intronic
chr13:73304142(+) A-I      intronic
chr13:73310008(+) A-I      intronic
chr13:73309841(+) A-I      intronic
chr13:73310009(+) A-I      intronic
chr13:73309848(+) A-I      intronic
chr13:73306588(+) A-I      intronic
chr13:73304975(+) A-I      intronic
chr13:73310021(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BORA
chr13:73304975(+) A-I intron -    22327324
chr13:73304975(+) A-G intron -    22484847
chr13:73306631(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BORA
chr13:73303120-73303121(+) m6A 5'UTR//CDS//exon//intron       24284625
chr13:73320682-73320683(+) m6A CDS       24284625//24981863//22608085
chr13:73320768-73320769(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr13:73320802-73320803(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr13:73320835-73320836(+) m6A CDS       24284625//24981863//22575960//22608085
chr13:73321052-73321053(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr13:73321099-73321100(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr13:73321181-73321182(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr13:73327917-73327918(+) m6A CDS       22608085
chr13:73329292-73329293(+) m6A CDS       22608085
chr13:73329321-73329322(+) m6A CDS       24284625//24981863//22608085
chr13:73329376-73329377(+) m6A 3'UTR       24284625//24981863//22575960//22608085
chr13:73329511-73329512(+) m6A 3'UTR       24284625//27773535//22608085
chr13:73329531-73329532(+) m6A 3'UTR       24284625//27773535//22608085
chr13:73329654-73329655(+) m6A 3'UTR       27773535
chr13:73329702-73329703(+) m6A 3'UTR       27773535
chr13:73329711-73329712(+) m6A 3'UTR       27773535
chr13:73329722-73329723(+) m6A 3'UTR       27773535
chr13:73330036-73330037(+) m6A 3'UTR       27773535
chr13:73330092-73330093(+) m6A 3'UTR       27773535
chr13:73330199-73330200(+) m6A 3'UTR       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
BORA
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: BORA

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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