Basic Information:

  VIRBase ID:  

HHID00011883

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          RBM25:  NM_021239     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	RBM25
miRBase Accession/Entrez ID	MIMAT0004593	58517
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	fSAP94//NET52//RED120//RNPC7//S164//Snu71

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RBM25	chr14:73546052(+) A-I      intronic chr14:73585000(+) A-I      intronic chr14:73536370(+) A-I      intronic chr14:73546027(+) A-I      intronic chr14:73556888(+) A-I      intronic chr14:73546017(+) A-I      intronic chr14:73585034(+) A-I      intronic chr14:73552990(+) A-I      intronic chr14:73584081(+) A-I      intronic chr14:73584089(+) A-I      intronic chr14:73587649(+) A-I      3'UTR chr14:73536369(+) A-I      intronic chr14:73585899(+) A-I      intronic chr14:73584974(+) A-I      intronic chr14:73584977(+) A-I      intronic chr14:73584988(+) A-I      intronic chr14:73585920(+) A-I      intronic chr14:73546043(+) A-I      intronic chr14:73546046(+) A-I      intronic chr14:73546051(+) A-I      intronic chr14:73585928(+) A-I      intronic chr14:73584043(+) A-I      intronic chr14:73584044(+) A-I      intronic chr14:73584065(+) A-I      intronic chr14:73585039(+) A-I      intronic chr14:73585925(+) A-I      intronic chr14:73585905(+) A-I      intronic chr14:73585898(+) A-I      intronic chr14:73585893(+) A-I      intronic chr14:73585886(+) A-I      intronic chr14:73585933(+) A-I      intronic chr14:73585931(+) A-I      intronic chr14:73537599(+) A-I      intronic chr14:73580174(+) A-I      intronic chr14:73544769(+) A-I      intronic chr14:73586149(+) A-I      intronic chr14:73536404(+) A-I      intronic chr14:73547588(+) A-I      intronic chr14:73561306(+) A-I      intronic chr14:73536350(+) A-I      intronic chr14:73562203(+) A-I      intronic chr14:73558174(+) A-I      intronic chr14:73535504(+) A-I      intronic chr14:73553516(+) A-I      intronic chr14:73558039(+) A-I      intronic chr14:73584950(+) A-I      intronic chr14:73555743(+) A-I      intronic chr14:73539688(+) A-I      intronic chr14:73556243(+) A-I      intronic chr14:73547138(+) A-I      intronic chr14:73561764(+) A-I      intronic chr14:73577384(+) A-I      intronic chr14:73558014(+) A-I      intronic chr14:73529919(+) A-I      intronic chr14:73553078(+) A-I      intronic chr14:73586175(+) A-I      intronic chr14:73580213(+) A-I      intronic chr14:73551389(+) A-I      intronic chr14:73552985(+) A-I      intronic chr14:73545495(+) A-I      intronic chr14:73553058(+) A-I      intronic chr14:73533834(+) A-I      intronic chr14:73535782(+) A-I      intronic chr14:73547971(+) A-I      intronic chr14:73540238(+) A-I      intronic chr14:73577398(+) A-I      intronic chr14:73553103(+) A-I      intronic chr14:73558432(+) A-I      intronic chr14:73551440(+) A-I      intronic chr14:73576550(+) A-I      intronic chr14:73565074(+) A-I      intronic chr14:73552986(+) A-I      intronic chr14:73552945(+) A-I      intronic chr14:73584959(+) A-I      intronic chr14:73551354(+) A-I      intronic chr14:73555672(+) A-I      intronic chr14:73556189(+) A-I      intronic chr14:73545853(+) A-I      intronic chr14:73562101(+) A-I      intronic chr14:73576347(+) A-I      intronic chr14:73552909(+) A-I      intronic chr14:73585141(+) A-I      intronic chr14:73586184(+) A-I      intronic chr14:73544812(+) A-I      intronic chr14:73558427(+) A-I      intronic chr14:73562150(+) A-I      intronic chr14:73545897(+) A-I      intronic chr14:73544659(+) A-I      intronic chr14:73533917(+) A-I      intronic chr14:73586155(+) A-I      intronic chr14:73537428(+) A-I      intronic chr14:73562270(+) A-I      intronic chr14:73545960(+) A-I      intronic chr14:73580215(+) A-I      intronic chr14:73562803(+) A-I      intronic chr14:73547602(+) A-I      intronic chr14:73547690(+) A-I      intronic chr14:73562885(+) A-I      intronic chr14:73549697(+) A-I      intronic chr14:73586235(+) A-I      intronic chr14:73530064(+) A-I      intronic chr14:73537528(+) A-I      intronic chr14:73558384(+) A-I      intronic chr14:73558318(+) A-I      intronic chr14:73581481(+) A-I      intronic chr14:73558316(+) A-I      intronic chr14:73540268(+) A-I      intronic chr14:73560341(+) A-I      intronic chr14:73560344(+) A-I      intronic chr14:73586139(+) A-I      intronic chr14:73558474(+) A-I      intronic chr14:73542087(+) A-I      intronic chr14:73555703(+) A-I      intronic chr14:73542022(+) A-I      intronic chr14:73533239(+) A-I      intronic chr14:73540351(+) A-I      intronic chr14:73540250(+) A-I      intronic chr14:73540246(+) A-I      intronic chr14:73580042(+) A-I      intronic chr14:73540124(+) A-I      intronic chr14:73537859(+) A-I      intronic chr14:73537856(+) A-I      intronic chr14:73584921(+) A-I      intronic chr14:73562235(+) A-I      intronic chr14:73544900(+) A-I      intronic chr14:73537401(+) A-I      intronic chr14:73584945(+) A-I      intronic chr14:73558068(+) A-I      intronic chr14:73533198(+) A-I      intronic chr14:73537794(+) A-I      intronic chr14:73558324(+) A-I      intronic chr14:73586172(+) A-I      intronic chr14:73537852(+) A-I      intronic chr14:73538941(+) A-I      intronic chr14:73555770(+) A-I      intronic chr14:73535493(+) A-I      intronic chr14:73551751(+) A-I      intronic chr14:73553493(+) A-I      intronic chr14:73533871(+) A-I      intronic chr14:73551390(+) A-I      intronic chr14:73560476(+) A-I      intronic chr14:73551365(+) A-I      intronic chr14:73551860(+) A-I      intronic chr14:73581440(+) A-I      intronic chr14:73536416(+) A-I      intronic chr14:73551364(+) A-I      intronic chr14:73556260(+) A-I      intronic chr14:73537819(+) A-I      intronic chr14:73562821(+) A-I      intronic chr14:73576341(+) A-I      intronic chr14:73556285(+) A-I      intronic chr14:73576364(+) A-I      intronic chr14:73555708(+) A-I      intronic chr14:73553517(+) A-I      intronic chr14:73586158(+) A-I      intronic chr14:73557958(+) A-I      intronic chr14:73531762(+) A-I      intronic chr14:73545876(+) A-I      intronic chr14:73580223(+) A-I      intronic chr14:73546011(+) A-I      intronic chr14:73580288(+) A-I      intronic chr14:73544756(+) A-I      intronic chr14:73565048(+) A-I      intronic chr14:73562869(+) A-I      intronic chr14:73580004(+) A-I      intronic chr14:73558511(+) A-I      intronic chr14:73577411(+) A-I      intronic chr14:73570436(+) A-I      intronic chr14:73537803(+) A-I      intronic chr14:73560799(+) A-I      intronic chr14:73547113(+) A-I      intronic chr14:73547871(+) A-I      intronic chr14:73560415(+) A-I      intronic chr14:73545969(+) A-I      intronic chr14:73581350(+) A-I      intronic chr14:73549129(+) A-I      intronic chr14:73545412(+) A-I      intronic chr14:73558438(+) A-I      intronic chr14:73558465(+) A-I      intronic chr14:73560380(+) A-I      intronic chr14:73530068(+) A-I      intronic chr14:73586180(+) A-I      intronic chr14:73531177(+) A-I      intronic chr14:73561692(+) A-I      intronic chr14:73536219(+) A-I      intronic chr14:73533839(+) A-I      intronic chr14:73545869(+) A-I      intronic chr14:73562167(+) A-I      intronic chr14:73549681(+) A-I      intronic chr14:73561726(+) A-I      intronic chr14:73585023(+) A-I      intronic chr14:73558157(+) A-I      intronic chr14:73553039(+) A-I      intronic chr14:73556931(+) A-I      intronic chr14:73561749(+) A-I      intronic chr14:73560278(+) A-I      intronic chr14:73552893(+) A-I      intronic chr14:73545898(+) A-I      intronic chr14:73556162(+) A-I      intronic chr14:73537862(+) A-I      intronic chr14:73534217(+) A-I      intronic chr14:73553035(+) A-I      intronic chr14:73585071(+) A-I      intronic chr14:73531678(+) A-I      intronic chr14:73561423(+) A-I      intronic chr14:73556514(+) A-I      intronic chr14:73553096(+) A-I      intronic chr14:73581479(+) A-I      intronic chr14:73564712(+) A-I      intronic chr14:73545978(+) A-I      intronic chr14:73584160(+) A-I      intronic chr14:73561626(+) A-I      intronic chr14:73540163(+) A-I      intronic chr14:73558015(+) A-I      intronic chr14:73553542(+) A-I      intronic chr14:73585195(+) A-I      intronic chr14:73549631(+) A-I      intronic chr14:73536258(+) A-I      intronic chr14:73556301(+) A-I      intronic chr14:73545393(+) A-I      intronic chr14:73551838(+) A-I      intronic chr14:73532315(+) A-I      intronic chr14:73545924(+) A-I      intronic chr14:73545502(+) A-I      intronic chr14:73562215(+) A-I      intronic chr14:73549515(+) A-I      intronic chr14:73533248(+) A-I      intronic chr14:73544658(+) A-I      intronic chr14:73585355(+) A-I      intronic chr14:73577399(+) A-I      intronic chr14:73533189(+) A-I      intronic chr14:73552987(+) A-I      intronic chr14:73561824(+) A-I      intronic chr14:73549633(+) A-I      intronic chr14:73549667(+) A-I      intronic chr14:73560279(+) A-I      intronic chr14:73552900(+) A-I      intronic chr14:73558062(+) A-I      intronic chr14:73553025(+) A-I      intronic chr14:73552988(+) A-I      intronic chr14:73536307(+) A-I      intronic chr14:73580177(+) A-I      intronic chr14:73534193(+) A-I      intronic chr14:73537567(+) A-I      intronic chr14:73585075(+) A-I      intronic chr14:73532400(+) A-I      intronic chr14:73532388(+) A-I      intronic chr14:73537469(+) A-I      intronic chr14:73561823(+) A-I      intronic chr14:73580166(+) A-I      intronic chr14:73528510(+) A-I      intronic chr14:73536346(+) A-I      intronic chr14:73585271(+) A-I      intronic chr14:73576246(+) A-I      intronic chr14:73547071(+) A-I      intronic chr14:73549188(+) A-I      intronic chr14:73545430(+) A-I      intronic chr14:73579576(+) A-I      intronic chr14:73553596(+) A-I      intronic chr14:73580220(+) A-I      intronic chr14:73533878(+) A-I      intronic chr14:73585883(+) A-I      intronic chr14:73585101(+) A-I      intronic chr14:73537442(+) A-I      intronic chr14:73562207(+) A-I      intronic chr14:73537432(+) A-I      intronic chr14:73555673(+) A-I      intronic chr14:73562106(+) A-I      intronic chr14:73560245(+) A-I      intronic chr14:73558380(+) A-I      intronic chr14:73545452(+) A-I      intronic chr14:73556111(+) A-I      intronic chr14:73552927(+) A-I      intronic chr14:73586234(+) A-I      intronic chr14:73533337(+) A-I      intronic chr14:73576354(+) A-I      intronic chr14:73552901(+) A-I      intronic chr14:73580135(+) A-I      intronic chr14:73562749(+) A-I      intronic chr14:73579992(+) A-I      intronic chr14:73552984(+) A-I      intronic chr14:73576545(+) A-I      intronic chr14:73576548(+) A-I      intronic chr14:73531158(+) A-I      intronic chr14:73556192(+) A-I      intronic chr14:73553587(+) A-I      intronic chr14:73580284(+) A-I      intronic chr14:73552417(+) A-I      intronic chr14:73562199(+) A-I      intronic chr14:73562223(+) A-I      intronic chr14:73532337(+) A-I      intronic chr14:73561730(+) A-I      intronic chr14:73584139(+) A-I      intronic chr14:73553436(+) A-I      intronic chr14:73581150(+) A-I      intronic chr14:73558325(+) A-I      intronic chr14:73558381(+) A-I      intronic chr14:73580221(+) A-I      intronic chr14:73541186(+) A-I      intronic chr14:73564708(+) A-I      intronic chr14:73561786(+) A-I      intronic chr14:73555671(+) A-I      intronic chr14:73585049(+) A-I      intronic chr14:73585881(+) A-I      intronic chr14:73584922(+) A-I      intronic chr14:73562153(+) A-I      intronic chr14:73537419(+) A-I      intronic chr14:73560396(+) A-I      intronic chr14:73585098(+) A-I      intronic chr14:73535888(+) A-I      intronic chr14:73580279(+) A-I      intronic chr14:73584120(+) A-I      intronic chr14:73537468(+) A-I      intronic chr14:73585065(+) A-I      intronic chr14:73553482(+) A-I      intronic chr14:73536178(+) A-I      intronic chr14:73537575(+) A-I      intronic chr14:73544860(+) A-I      intronic chr14:73544619(+) A-I      intronic chr14:73556202(+) A-I      intronic chr14:73553578(+) A-I      intronic chr14:73555755(+) A-I      intronic chr14:73560399(+) A-I      intronic chr14:73545517(+) A-I      intronic chr14:73545364(+) A-I      intronic chr14:73558594(+) A-I      intronic chr14:73580056(+) A-I      intronic chr14:73585120(+) A-I      intronic chr14:73553477(+) A-I      intronic chr14:73551828(+) A-I      intronic chr14:73536897(+) A-I      intronic chr14:73584928(+) A-I      intronic chr14:73584998(+) A-I      intronic chr14:73557956(+) A-I      intronic chr14:73552970(+) A-I      intronic chr14:73585043(+) A-I      intronic chr14:73536813(+) A-I      intronic chr14:73535795(+) A-I      intronic chr14:73537839(+) A-I      intronic chr14:73536945(+) A-I      intronic chr14:73580057(+) A-I      intronic chr14:73533082(+) A-I      intronic chr14:73561588(+) A-I      intronic chr14:73585882(+) A-I      intronic chr14:73536259(+) A-I      intronic chr14:73585002(+) A-I      intronic chr14:73545586(+) A-I      intronic chr14:73585501(+) A-I      intronic chr14:73564716(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RBM25	chr14:73545452(+) A-I intron -    21960545 chr14:73556162(+) A-I intron -    21960545 chr14:73564712(+) A-I intron -    21960545 chr14:73564716(+) A-I intron -    21960545 chr14:73567070(+) T-G intron -    21725310 chr14:73552900(+) A-G intron -    22484847 chr14:73553596(+) A-G intron -    22484847 chr14:73570436(+) A-G intron -    22484847 chr14:73585002(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RBM25	chr14:73525243-73525244(+) m6A 5'UTR       24284625//24981863//22575960//22608085 chr14:73525344-73525345(+) m6A 5'UTR//exon       24284625//24981863//22575960//22608085 chr14:73525443-73525444(+) m6A 5'UTR//intron       24284625//24981863 chr14:73525451-73525452(+) m6A 5'UTR//intron       24284625//24981863 chr14:73536621-73536622(+) m6A 5'UTR//intron       24284625 chr14:73554818-73554819(+) m6A CDS//exon       24981863//27773535 chr14:73555106-73555107(+) m6A 3'UTR//intron       24981863//27773535 chr14:73555141-73555142(+) m6A 3'UTR//intron       24981863//27773535 chr14:73555151-73555152(+) m6A 3'UTR//intron       24981863//27773535 chr14:73563637-73563638(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr14:73563676-73563677(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr14:73566402-73566403(+) m1A 3'UTR//CDS//exon       26863196 chr14:73566405-73566406(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr14:73566414-73566415(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr14:73566428-73566429(+) Gm 3'UTR//CDS//exon       - chr14:73566447-73566448(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr14:73566494-73566495(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535//22608085 chr14:73566521-73566522(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535//22608085 chr14:73567037-73567038(+) m6A 3'UTR//exon//intron       27773535 chr14:73569901-73569902(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr14:73569909-73569910(+) m1A 3'UTR//CDS//exon       26863196 chr14:73569937-73569938(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73570080-73570081(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73570091-73570092(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73570104-73570105(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73570107-73570108(+) Gm 3'UTR//CDS//exon       - chr14:73572694-73572695(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73572706-73572707(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73572715-73572716(+) Am 3'UTR//CDS//exon       - chr14:73572715-73572716(+) m1A 3'UTR//CDS//exon       26863196 chr14:73572724-73572725(+) m1A 3'UTR//CDS//exon       26863196 chr14:73572746-73572747(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73572758-73572759(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr14:73572939-73572940(+) m6A 3'UTR//CDS//exon       24209618//25456834//24981863//27773535//27371828//22608085 chr14:73572973-73572974(+) m1A 3'UTR//CDS//exon       26863196 chr14:73572983-73572984(+) m1A 3'UTR//CDS//exon       26863196 chr14:73574059-73574060(+) m6A exon//intron       25456834//24981863//27773535//22608085 chr14:73574075-73574076(+) m6A exon//intron       25456834//24981863//27773535//22608085 chr14:73574570-73574571(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr14:73575920-73575921(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr14:73575928-73575929(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr14:73576108-73576109(+) Gm 3'UTR//CDS//exon       - chr14:73577543-73577544(+) m6A 3'UTR//CDS//exon       24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr14:73577608-73577609(+) m1A 3'UTR//CDS//exon       26863196 chr14:73577642-73577643(+) m6A 3'UTR//CDS//exon       24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr14:73577687-73577688(+) m6A 3'UTR//CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085 chr14:73578281-73578282(+) m6A 3'UTR//CDS//exon       27773535 chr14:73578322-73578323(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr14:73578350-73578351(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr14:73578406-73578407(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr14:73578425-73578426(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr14:73578464-73578465(+) m6A 3'UTR//CDS//exon       24981863 chr14:73578882-73578883(+) m6A 3'UTR//CDS//exon       24981863 chr14:73586879-73586880(+) m6A 3'UTR//exon       22608085 chr14:73586889-73586890(+) m6A 3'UTR//exon       22608085 chr14:73586905-73586906(+) m6A 3'UTR//exon       22608085 chr14:73586918-73586919(+) m6A 3'UTR//exon       22608085 chr14:73587791-73587792(+) m6A 3'UTR//exon       27773535 chr14:73587920-73587921(+) m6A 3'UTR//exon       27773535 chr14:73587935-73587936(+) m6A 3'UTR//exon       27773535 chr14:73587945-73587946(+) m6A 3'UTR//exon       27773535 chr14:73587964-73587965(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RBM25	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: RBM25

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).