Detail Information

Basic Information:


  VIRBase ID:  

HHID00011858

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           ATXN7L3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p ATXN7L3
miRBase
Accession/Entrez ID		 MIMAT0004593 56970
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SGF11

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ATXN7L3
chr17:42269190-42269191(-) m6A 3'UTR       27773535
chr17:42270108-42270109(-) m6A 3'UTR       24284625//25456834//24981863//22608085
chr17:42270142-42270143(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr17:42270161-42270162(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085
chr17:42270177-42270178(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr17:42270186-42270187(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr17:42270247-42270248(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr17:42270325-42270326(-) m6A 3'UTR       24284625//27371828//22608085
chr17:42270426-42270427(-) m6A 3'UTR       24284625
chr17:42271050-42271051(-) m6A 3'UTR       24284625
chr17:42271276-42271277(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:42271281-42271282(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:42271400-42271401(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:42271416-42271417(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:42271422-42271423(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:42271428-42271429(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:42271716-42271717(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:42271752-42271753(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:42272166-42272167(-) m6A CDS//exon       27773535
chr17:42272233-42272234(-) m6A exon//intron       27773535
chr17:42273411-42273412(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr17:42273445-42273446(-) m6A 5'UTR//CDS//exon//intron       24981863//27773535
chr17:42273578-42273579(-) m6A exon//intron       24981863
chr17:42273767-42273768(-) m6A CDS//intron       24981863
chr17:42274619-42274620(-) m6A CDS//intron       24284625//24981863
chr17:42274732-42274733(-) m6A CDS//intron       24284625//24981863//22575960
chr17:42274742-42274743(-) m6A CDS//intron       24284625//24981863//27773535//22575960
chr17:42274757-42274758(-) m6A CDS//intron       24284625//24981863//27773535//22575960
chr17:42274988-42274989(-) m6A CDS//intron       24284625//24981863//27773535//22575960
chr17:42275072-42275073(-) m6A CDS//intron       24284625//24209618//24981863//27773535
chr17:42275393-42275394(-) m6A CDS//intron       24284625//24209618//27773535
chr17:42275531-42275532(-) m6A 5'UTR//intron       24209618//27371828
chr17:42275589-42275590(-) m6A 5'UTR//intron       25456834//24981863//27371828
chr17:42275603-42275604(-) m6A 5'UTR//intron       25456834//24981863//27371828
chr17:42275635-42275636(-) m6A 5'UTR//intron       25456834//27371828
chr17:42275644-42275645(-) m6A 5'UTR//intron       27371828
chr17:42275677-42275678(-) m6A 5'UTR//intron       27371828
chr17:42276564-42276565(-) m6A 5'UTR//intron       24209618
chr17:42276954-42276955(-) m6A 5'UTR//intron       24209618//27773536
chr17:42276962-42276963(-) m6A 5'UTR//intron       24209618//27773536
chr17:42277070-42277071(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536
chr17:42277116-42277117(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
ATXN7L3
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: ATXN7L3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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