Detail Information

Basic Information:


  VIRBase ID:  

HHID00011785

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           MDFIC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p MDFIC
miRBase
Accession/Entrez ID		 MIMAT0004593 29969
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HIC//MDFIC1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MDFIC
chr7:114642033(+) A-I      intronic
chr7:114642014(+) A-I      intronic
chr7:114642089(+) A-I      intronic
chr7:114642071(+) A-I      intronic
chr7:114623752(+) A-I      intronic
chr7:114604723(+) A-I      intronic
chr7:114652854(+) A-I      intronic
chr7:114652975(+) A-I      intronic
chr7:114604705(+) A-I      intronic
chr7:114652853(+) A-I      intronic
chr7:114647936(+) A-I      intronic
chr7:114647805(+) A-I      intronic
chr7:114647802(+) A-I      intronic
chr7:114642210(+) A-I      intronic
chr7:114642199(+) A-I      intronic
chr7:114656462(+) A-I      3'UTR
chr7:114656453(+) A-I      3'UTR
chr7:114656432(+) A-I      3'UTR
chr7:114656431(+) A-I      3'UTR
chr7:114656472(+) A-I      3'UTR
chr7:114647759(+) A-I      intronic
chr7:114598731(+) A-I      intronic
chr7:114647907(+) A-I      intronic
chr7:114622689(+) A-I      intronic
chr7:114647765(+) A-I      intronic
chr7:114637650(+) A-I      intronic
chr7:114652849(+) A-I      intronic
chr7:114642178(+) A-I      intronic
chr7:114652846(+) A-I      intronic
chr7:114647814(+) A-I      intronic
chr7:114647889(+) A-I      intronic
chr7:114652886(+) A-I      intronic
chr7:114652799(+) A-I      intronic
chr7:114591120(+) A-I      intronic
chr7:114603769(+) A-I      intronic
chr7:114641966(+) A-I      intronic
chr7:114642044(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MDFIC
chr7:114658248(+) A-C intron -    21725310
chr7:114598731(+) A-G intron -    22484847
chr7:114604629(+) A-G intron -    22484847
chr7:114608007(+) T-C intron -    22484847
chr7:114623698(+) A-C intron -    22484847
chr7:114641966(+) A-G intron -    22484847
chr7:114642019(+) T-C intron -    22484847
chr7:114642024(+) G-C intron -    22484847
chr7:114642044(+) A-G intron -    22484847
chr7:114642178(+) A-G intron -    22484847
chr7:114647759(+) A-G intron -    22484847
chr7:114647765(+) A-G intron -    22484847
chr7:114647814(+) A-G intron -    22484847
chr7:114647889(+) A-G intron -    22484847
chr7:114652799(+) A-G intron -    22484847
chr7:114652849(+) A-G intron -    22484847
chr7:114652886(+) A-G intron -    22484847
chr7:114656743(+) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MDFIC
chr7:114562237-114562238(+) m6A 5'UTR       24981863
chr7:114562944-114562945(+) m6A 5'UTR//intron       24209618//24981863
chr7:114655811-114655812(+) m6A 3'UTR//CDS       24981863
chr7:114655903-114655904(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr7:114655939-114655940(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr7:114656014-114656015(+) m6A 3'UTR       24981863//22608085
chr7:114656487-114656488(+) m6A 3'UTR       -
chr7:114656510-114656511(+) m6A 3'UTR       -
chr7:114656607-114656608(+) m6A 3'UTR       24981863
chr7:114656651-114656652(+) m6A 3'UTR       24981863
chr7:114656688-114656689(+) m6A 3'UTR       24981863
chr7:114656741-114656742(+) m6A 3'UTR       24981863//27773535
chr7:114656767-114656768(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656777-114656778(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656781-114656782(+) m6A 3'UTR       24981863
chr7:114656800-114656801(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656845-114656846(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656867-114656868(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656881-114656882(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656890-114656891(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656920-114656921(+) m6A 3'UTR       24981863//27773535//22608085
chr7:114656936-114656937(+) m6A 3'UTR       24981863//22608085
chr7:114656960-114656961(+) m6A 3'UTR       24981863//22608085
chr7:114657005-114657006(+) m6A 3'UTR       24981863
chr7:114658077-114658078(+) Y 3'UTR       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MDFIC
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: MDFIC

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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