Basic Information:

  VIRBase ID:  

HHID00011756

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          CEMIP2:  NM_001135820     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	CEMIP2
miRBase Accession/Entrez ID	MIMAT0004593	23670
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEMIP2	chr9:74356307(-) A-I      intronic chr9:74356651(-) A-I      intronic chr9:74322937(-) A-I      intronic chr9:74322935(-) A-I      intronic chr9:74321830(-) A-I      intronic chr9:74321779(-) A-I      intronic chr9:74321069(-) A-I      intronic chr9:74302730(-) A-I      intronic chr9:74356843(-) A-I      intronic chr9:74356326(-) A-I      intronic chr9:74321063(-) A-I      intronic chr9:74321062(-) A-I      intronic chr9:74356290(-) A-I      intronic chr9:74321123(-) A-I      intronic chr9:74320981(-) A-I      intronic chr9:74320979(-) A-I      intronic chr9:74320901(-) A-I      intronic chr9:74356291(-) A-I      intronic chr9:74303411(-) A-I      intronic chr9:74303416(-) A-I      intronic chr9:74303433(-) A-I      intronic chr9:74306123(-) A-I      intronic chr9:74306127(-) A-I      intronic chr9:74306132(-) A-I      intronic chr9:74306137(-) A-I      intronic chr9:74306163(-) A-I      intronic chr9:74321855(-) A-I      intronic chr9:74356289(-) A-I      intronic chr9:74356254(-) A-I      intronic chr9:74356251(-) A-I      intronic chr9:74302865(-) A-I      intronic chr9:74302870(-) A-I      intronic chr9:74302878(-) A-I      intronic chr9:74353307(-) A-I      intronic chr9:74344528(-) A-I      intronic chr9:74317111(-) A-I      intronic chr9:74317079(-) A-I      intronic chr9:74317074(-) A-I      intronic chr9:74302884(-) A-I      intronic chr9:74316289(-) A-I      intronic chr9:74316286(-) A-I      intronic chr9:74316259(-) A-I      intronic chr9:74316199(-) A-I      intronic chr9:74316189(-) A-I      intronic chr9:74316160(-) A-I      intronic chr9:74316159(-) A-I      intronic chr9:74316154(-) A-I      intronic chr9:74316133(-) A-I      intronic chr9:74317066(-) A-I      intronic chr9:74307742(-) A-I      intronic chr9:74306290(-) A-I      intronic chr9:74303583(-) A-I      intronic chr9:74303550(-) A-I      intronic chr9:74303005(-) A-I      intronic chr9:74302864(-) A-I      intronic chr9:74303401(-) A-I      intronic chr9:74302699(-) A-I      intronic chr9:74302523(-) A-I      intronic chr9:74344478(-) A-I      intronic chr9:74344051(-) A-I      intronic chr9:74344045(-) A-I      intronic chr9:74344023(-) A-I      intronic chr9:74343077(-) A-I      intronic chr9:74303397(-) A-I      intronic chr9:74343031(-) A-I      intronic chr9:74323055(-) A-I      intronic chr9:74303410(-) A-I      intronic chr9:74322981(-) A-I      intronic chr9:74321919(-) A-I      intronic chr9:74322979(-) A-I      intronic chr9:74302526(-) A-I      intronic chr9:74303599(-) A-I      intronic chr9:74302880(-) A-I      intronic chr9:74321914(-) A-I      intronic chr9:74302897(-) A-I      intronic chr9:74344508(-) A-I      intronic chr9:74316198(-) A-I      intronic chr9:74322913(-) A-I      intronic chr9:74302553(-) A-I      intronic chr9:74343286(-) A-I      intronic chr9:74309115(-) A-I      intronic chr9:74344029(-) A-I      intronic chr9:74317140(-) A-I      intronic chr9:74343815(-) A-I      intronic chr9:74321915(-) A-I      intronic chr9:74333668(-) A-I      intronic chr9:74370628(-) A-I      intronic chr9:74356821(-) A-I      intronic chr9:74343037(-) A-I      intronic chr9:74359073(-) A-I      intronic chr9:74333666(-) A-I      intronic chr9:74302706(-) A-I      intronic chr9:74320960(-) A-I      intronic chr9:74343850(-) A-I      intronic chr9:74343392(-) A-I      intronic chr9:74365900(-) A-I      intronic chr9:74370262(-) A-I      intronic chr9:74322857(-) A-I      intronic chr9:74343786(-) A-I      intronic chr9:74322017(-) A-I      intronic chr9:74316294(-) A-I      intronic chr9:74351919(-) A-I      intronic chr9:74344037(-) A-I      intronic chr9:74321836(-) A-I      intronic chr9:74302500(-) A-I      intronic chr9:74321023(-) A-I      intronic chr9:74344472(-) A-I      intronic chr9:74344279(-) A-I      intronic chr9:74356286(-) A-I      intronic chr9:74344346(-) A-I      intronic chr9:74302889(-) A-I      intronic chr9:74333631(-) A-I      intronic chr9:74348943(-) A-I      intronic chr9:74343840(-) A-I      intronic chr9:74306114(-) A-I      intronic chr9:74303443(-) A-I      intronic chr9:74344354(-) A-I      intronic chr9:74348942(-) A-I      intronic chr9:74343949(-) A-I      intronic chr9:74321873(-) A-I      intronic chr9:74302527(-) A-I      intronic chr9:74359088(-) A-I      intronic chr9:74321841(-) A-I      intronic chr9:74322921(-) A-I      intronic chr9:74302991(-) A-I      intronic chr9:74317143(-) A-I      intronic chr9:74303064(-) A-I      intronic chr9:74310369(-) A-I      intronic chr9:74307707(-) A-I      intronic chr9:74321882(-) A-I      intronic chr9:74309318(-) A-I      intronic chr9:74344028(-) A-I      intronic chr9:74310328(-) A-I      intronic chr9:74321840(-) A-I      intronic chr9:74302470(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CEMIP2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: CEMIP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).