Detail Information

Basic Information:


  VIRBase ID:  

HHID00011731

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           MAPRE1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p MAPRE1
miRBase
Accession/Entrez ID		 MIMAT0004593 22919
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EB1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAPRE1
chr20:31408921(+) A-I      intronic
chr20:31415050(+) A-I      intronic
chr20:31414979(+) A-I      intronic
chr20:31414584(+) A-I      intronic
chr20:31414302(+) A-I      intronic
chr20:31414162(+) A-I      intronic
chr20:31415052(+) A-I      intronic
chr20:31433082(+) A-I      intronic
chr20:31433067(+) A-I      intronic
chr20:31423787(+) A-I      intronic
chr20:31421015(+) A-I      intronic
chr20:31419624(+) A-I      intronic
chr20:31418982(+) A-I      intronic
chr20:31416827(+) A-I      intronic
chr20:31415053(+) A-I      intronic
chr20:31414575(+) A-I      intronic
chr20:31415153(+) A-I      intronic
chr20:31415134(+) A-I      intronic
chr20:31414445(+) A-I      intronic
chr20:31411535(+) A-I      intronic
chr20:31420374(+) A-I      intronic
chr20:31419615(+) A-I      intronic
chr20:31414957(+) A-I      intronic
chr20:31414558(+) A-I      intronic
chr20:31418804(+) A-I      intronic
chr20:31415094(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAPRE1
chr20:31407789-31407790(+) m6A 5'UTR       24981863
chr20:31421604-31421605(+) m6A CDS       27773535
chr20:31427569-31427570(+) m6A CDS       22575960
chr20:31427612-31427613(+) m6A CDS       -
chr20:31434437-31434438(+) m6A CDS       27773535
chr20:31434451-31434452(+) m6A CDS       27773535
chr20:31434493-31434494(+) m6A CDS       24981863//27773535
chr20:31434556-31434557(+) m6A CDS       24981863//27773535//22608085
chr20:31436542-31436543(+) m6A 3'UTR       24981863//27773535//22608085
chr20:31436622-31436623(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr20:31436767-31436768(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr20:31436875-31436876(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr20:31437030-31437031(+) m6A 3'UTR       24284625
chr20:31437038-31437039(+) m6A 3'UTR       24284625
chr20:31437047-31437048(+) m6A 3'UTR       24284625
chr20:31437081-31437082(+) m6A 3'UTR       24284625
chr20:31438001-31438002(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MAPRE1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: MAPRE1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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