Basic Information:

  VIRBase ID:  

HHID00011717

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          NUDT21:  NM_007006     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	NUDT21
miRBase Accession/Entrez ID	MIMAT0004593	11051
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CFIM25//CPSF5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NUDT21	chr16:56469204(-) A-I      intronic chr16:56469213(-) A-I      intronic chr16:56469214(-) A-I      intronic chr16:56469244(-) A-I      intronic chr16:56477292(-) A-I      intronic chr16:56469395(-) A-I      intronic chr16:56477301(-) A-I      intronic chr16:56469088(-) A-I      intronic chr16:56469200(-) A-I      intronic chr16:56469282(-) A-I      intronic chr16:56469394(-) A-I      intronic chr16:56469396(-) A-I      intronic chr16:56469624(-) A-I      intronic chr16:56475426(-) A-I      intronic chr16:56477118(-) A-I      intronic chr16:56477119(-) A-I      intronic chr16:56477127(-) A-I      intronic chr16:56477217(-) A-I      intronic chr16:56477221(-) A-I      intronic chr16:56479089(-) A-I      intronic chr16:56478894(-) A-I      intronic chr16:56469212(-) A-I      intronic chr16:56477261(-) A-I      intronic chr16:56474980(-) A-I      intronic chr16:56469173(-) A-I      intronic chr16:56478973(-) A-I      intronic chr16:56479009(-) A-I      intronic chr16:56478879(-) A-I      intronic chr16:56479074(-) A-I      intronic chr16:56478851(-) A-I      intronic chr16:56478933(-) A-I      intronic chr16:56478885(-) A-I      intronic chr16:56474941(-) A-I      intronic chr16:56478080(-) A-I      intronic chr16:56469108(-) A-I      intronic chr16:56478823(-) A-I      intronic chr16:56469174(-) A-I      intronic chr16:56479039(-) A-I      intronic chr16:56469474(-) A-I      intronic chr16:56478930(-) A-I      intronic chr16:56469210(-) A-I      intronic chr16:56478928(-) A-I      intronic chr16:56478084(-) A-I      intronic chr16:56477961(-) A-I      intronic chr16:56478384(-) A-I      intronic chr16:56475281(-) A-I      intronic chr16:56479057(-) A-I      intronic chr16:56478839(-) A-I      intronic chr16:56475245(-) A-I      intronic chr16:56478884(-) A-I      intronic chr16:56469203(-) A-I      intronic chr16:56477227(-) A-I      intronic chr16:56469471(-) A-I      intronic chr16:56469217(-) A-I      intronic chr16:56469382(-) A-I      intronic chr16:56474815(-) A-I      intronic chr16:56477359(-) A-I      intronic chr16:56479013(-) A-I      intronic chr16:56475277(-) A-I      intronic chr16:56479049(-) A-I      intronic chr16:56478196(-) A-I      intronic chr16:56477295(-) A-I      intronic chr16:56478194(-) A-I      intronic chr16:56469490(-) A-I      intronic chr16:56469205(-) A-I      intronic chr16:56477262(-) A-I      intronic chr16:56469298(-) A-I      intronic chr16:56477306(-) A-I      intronic chr16:56477365(-) A-I      intronic chr16:56476012(-) A-I      intronic chr16:56477381(-) A-I      intronic chr16:56478852(-) A-I      intronic chr16:56477942(-) A-I      intronic chr16:56476066(-) A-I      intronic chr16:56469299(-) A-I      intronic chr16:56469065(-) A-I      intronic chr16:56474840(-) A-I      intronic chr16:56475440(-) A-I      intronic chr16:56478972(-) A-I      intronic chr16:56469489(-) A-I      intronic chr16:56467888(-) A-I      intronic chr16:56478984(-) A-I      intronic chr16:56475956(-) A-I      intronic chr16:56478924(-) A-I      intronic chr16:56478974(-) A-I      intronic chr16:56478144(-) A-I      intronic chr16:56477358(-) A-I      intronic chr16:56477226(-) A-I      intronic chr16:56469211(-) A-I      intronic chr16:56475260(-) A-I      intronic chr16:56469078(-) A-I      intronic chr16:56469380(-) A-I      intronic chr16:56476021(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NUDT21	chr16:56478823(-) A-I intron -    22028664 chr16:56478839(-) A-I intron -    22028664 chr16:56478851(-) A-I intron -    22028664 chr16:56478852(-) A-I intron -    22028664 chr16:56478879(-) A-I intron -    22028664 chr16:56478885(-) A-I intron -    22028664 chr16:56478894(-) A-I intron -    22028664 chr16:56478924(-) A-I intron -    22028664 chr16:56478928(-) A-I intron -    22028664 chr16:56478930(-) A-I intron -    22028664 chr16:56478933(-) A-I intron -    22028664 chr16:56478972(-) A-I intron -    22028664 chr16:56478973(-) A-I intron -    22028664 chr16:56478974(-) A-I intron -    22028664 chr16:56478984(-) A-I intron -    22028664 chr16:56479009(-) A-I intron -    22028664 chr16:56479013(-) A-I intron -    22028664 chr16:56479039(-) A-I intron -    22028664 chr16:56479074(-) A-I intron -    22028664 chr16:56479089(-) A-I intron -    22028664 chr16:56464388(-) C-T exon 3'UTR    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NUDT21	chr16:56465647-56465648(-) m6A 3'UTR       27773535 chr16:56465687-56465688(-) m6A 3'UTR       27773535 chr16:56465706-56465707(-) m6A 3'UTR       27773535 chr16:56465972-56465973(-) m6A 3'UTR       27773535 chr16:56466022-56466023(-) m6A 3'UTR       27773535 chr16:56466033-56466034(-) m6A 3'UTR       27773535 chr16:56466040-56466041(-) m6A 3'UTR       27773535 chr16:56466106-56466107(-) m6A 3'UTR       - chr16:56466164-56466165(-) m6A 3'UTR       - chr16:56473080-56473081(-) m6A exon//intron       24981863 chr16:56473112-56473113(-) m6A exon//intron       24981863 chr16:56473123-56473124(-) m6A exon//intron       24981863 chr16:56473154-56473155(-) m6A exon//intron       24981863 chr16:56473179-56473180(-) m6A exon//intron       24981863 chr16:56481716-56481717(-) m6A CDS//exon       26404942 chr16:56481782-56481783(-) m6A CDS//exon       26404942//27773535 chr16:56481847-56481848(-) m6A 5'UTR//CDS//exon       26404942//27773535 chr16:56485083-56485084(-) m6A CDS//exon//intron       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NUDT21	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: NUDT21

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).