Basic Information:

  VIRBase ID:  

HHID00011687

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          SPRY2:  NM_001318536     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	SPRY2
miRBase Accession/Entrez ID	MIMAT0004593	10253
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hSPRY2//IGAN3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPRY2	chr13:80910901-80910902(-) m6A CDS       24981863//27773535 chr13:80910911-80910912(-) m6A CDS       24981863//27773535 chr13:80910950-80910951(-) m6A CDS       24981863//27773535 chr13:80910956-80910957(-) m6A CDS       24981863//27773535 chr13:80911136-80911137(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr13:80911191-80911192(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr13:80911247-80911248(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr13:80911301-80911302(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr13:80911438-80911439(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr13:80911444-80911445(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr13:80911470-80911471(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr13:80911597-80911598(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr13:80911606-80911607(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr13:80911648-80911649(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr13:80911688-80911689(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr13:80911771-80911772(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr13:80911844-80911845(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22608085 chr13:80913020-80913021(-) m6A 5'UTR//intron       27371828 chr13:80913085-80913086(-) m6A 5'UTR//intron       27371828 chr13:80913787-80913788(-) m6A 5'UTR//intron       - chr13:80914184-80914185(-) m6A intron       25456834 chr13:80914827-80914828(-) m6A 5'UTR       25456834//24981863//27773535 chr13:80914946-80914947(-) m6A 5'UTR       24981863//27773535 chr13:80915039-80915040(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SPRY2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: SPRY2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).