Detail Information

Basic Information:


  VIRBase ID:  

HHID00011685

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           CALCRL:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p CALCRL
miRBase
Accession/Entrez ID		 MIMAT0004593 10203
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGRPR//CRLR//LMPHM8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CALCRL
chr2:188253993(-) A-I      intronic
chr2:188253973(-) A-I      intronic
chr2:188253970(-) A-I      intronic
chr2:188253964(-) A-I      intronic
chr2:188254003(-) A-I      intronic
chr2:188283686(-) A-I      intronic
chr2:188283721(-) A-I      intronic
chr2:188253923(-) A-I      intronic
chr2:188253937(-) A-I      intronic
chr2:188253938(-) A-I      intronic
chr2:188254079(-) A-I      intronic
chr2:188283748(-) A-I      intronic
chr2:188283805(-) A-I      intronic
chr2:188283744(-) A-I      intronic
chr2:188283820(-) A-I      intronic
chr2:188283829(-) A-I      intronic
chr2:188283837(-) A-I      intronic
chr2:188283856(-) A-I      intronic
chr2:188283722(-) A-I      intronic
chr2:188283806(-) A-I      intronic
chr2:188254073(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CALCRL
chr2:188210831-188210832(-) m6A 3'UTR       24981863//27773535//22608085
chr2:188210854-188210855(-) m6A 3'UTR       24981863//27773535//22608085
chr2:188210860-188210861(-) m6A 3'UTR       24981863//27773535//22608085
chr2:188210931-188210932(-) m6A CDS       24981863//27773535//22608085
chr2:188210979-188210980(-) m6A CDS       27773535
chr2:188312930-188312931(-) m6A 5'UTR//exon       24981863
chr2:188312975-188312976(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
CALCRL
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: CALCRL

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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